摘要
谷氨酸与去甲肾上腺素及其对应受体分别构成谷氨酸能系统和去甲肾上腺素能系统,二者在多种神经精神疾病过程中发挥重要作用,并且存在密切对话。该文回顾了高级中枢神经系统中谷氨酸受体——N-甲基-D-天冬氨酸受体(Nmethyl-D-aspartate receptor,NMDA-R)和肾上腺素受体——α_(2)肾上腺素受体(alpha 2 adrenergic receptor,α_(2)-AR)参与神经精神疾病的具体分子机制,以及二者可能的对话机制,对深入认识两种受体相关神经精神疾病的神经生物学机制、药物研发和优化临床治疗方案具有重要意义。
Glutamate,norepinephrine,and their receptors comprise the glutamatergic and norepinephrine systems,which mutually affect each other and play essential roles in mediating various neuropsychiatric diseases.This paper reviews the functions of N-methyl-D-aspartate receptor(NMDA-R)andα2-adrenergic receptor(α2-AR)and their functional crosstalk at the molecular level in brain in common neuropsychiatric diseases,which would benefit our understanding of neuropathophysiology of psychiatric diseases,drug development and optimization of clinical neuropsychopharmacology.
作者
章文欣
周冬雨
韩奕
季然
艾琳
谢安
翟晓静
曹君利
张红星
ZHANG Wen-xin;ZHOU Dong-yu;HAN Yi;JI Ran;AI Lin;XIE An;ZHAI Xiao-jing;CAO Jun-li;ZHANG Hong-xing(Jiangsu Province Key Laboratory of Anesthesiology,Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology,Key Laboratory of Research and Evaluation of Narcotic Psychotropic Drugs of the State Medical Products Administration,Xuzhou Jiangsu 221004,China;Dept of Anesthesiology,Affiliated Hospital of Xuzhou Medical University,Xuzhou Jiangsu 221002,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2024年第12期2206-2212,共7页
Chinese Pharmacological Bulletin
基金
科技创新2030重大项目(No 2021ZD0203100)
国家自然科学基金资助项目(No 31970937,82271255)
江苏省研究生科研与实践创新计划项目(No KYCX22_2918、2932)。
