摘要
围手术期神经认知功能障碍(PND)可严重损害患者的神经认知功能,延长住院时间,导致病死率增高及远期预后不良。睡眠紊乱被认为是诱发PND的重要因素,但其在PND发生过程中的作用尚不明确,而围手术期积极干预睡眠紊乱能否有效预防PND亦存在争议。为此,本文阐述了睡眠的基本功能与调控,围手术期睡眠紊乱的临床特征及其在PND发生中的作用,并进一步探讨了调控睡眠紊乱干预PND的潜在治疗策略,以指导临床改善患者的神经功能预后及远期转归。
Perioperative neurocognitive disorder(PND)significantly threatens brain health,leading to prolonged hospitalization,increased patient mortality risk,and poor long-term prognosis.Sleep disorder may substantially elevate the risk of neurocognitive dysfunction.However,the specific role of sleep in PND development remains to be elucidated.In addition,controversy exists over whether interventions for perioperative sleep disorder can effectively prevent PND.Therefore,this review aims to explore the basic function and regulatory principles of sleep,the clinical characteristics of perioperative sleep disorder,its role and potential mechanisms in PND development.Furthermore,we also provide new evidence on the potential therapeutic strategies to modulate sleep disorder for PND management,to improve patient's neurocognitive prognosis and long-term outcomes.
作者
查超超
李峙林
王英伟
罗猛强
Zha Chao-Chao;Li Shi-Lin;Wang Ying-Wei;Luo Meng-Qiang(Department of Anesthesiology,Huashan Hospital Affiliated to Hehai University,Shanghai 200040,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2024年第10期1099-1104,共6页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金(82371286,82101350,82271292)
上海市“科技创新行动计划”医学创新研究专项(23Y2190600)。
关键词
睡眠紊乱
全身麻醉
围手术期神经认知功能障碍
睡眠调控
sleep disorders
general anesthesia
perioperative neurocognitive disorder
sleep modulation
