摘要
目的 探究麻射安金丸联合乙酰半胱氨酸雾化吸入治疗对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者痰液黏稠度及氧代谢的影响。方法 纳入2021年7月至2023年10月本院收治的AECOPD患者120例,并采用随机数字表法分为西药组和联合组,每组60例。西药组在常规治疗基础上予吸入用乙酰半胱氨酸溶液雾化吸入治疗,联合组在西药组基础上加用麻射安金丸口服,两组均连续治疗14 d。治疗前后分别检测、记录两组痰液黏稠度、血气分析指标[二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))和氧饱和度(SaO_(2))]、肺通气功能指标[用力肺活量(forced vital capacity,FVC)、第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))和FEV_(1)/FVC]的变化情况,同时比较两组临床疗效。结果 治疗后,西药组总有效率低于联合组(75.00% vs 93.33%,P<0.05)。治疗后,两组痰液黏稠度均有所改善,且联合组改善程度优于西药组(P<0.05);两组SaO_(2)和PaO_(2)均较前升高(P<0.05),PaCO_(2)均降低(P<0.05),且联合组SaO_(2)和PaO_(2)高于西药组(P<0.05),PaCO_(2)低于西药组(P<0.05)。治疗后,两组FVC、FEV_(1)及FEV_(1)/FVC均较前升高(P<0.05),且联合组高于西药组(P<0.05)。两组不良反应发生率无显著差异(P>0.05)。结论 麻射安金丸联合乙酰半胱氨酸雾化吸入治疗AECOPD患者可有效降低痰液黏稠度,改善氧代谢和肺通气功能,提高临床疗效。
Objective To investigate the effects of Mashe Anjin pill combined with acetylcysteine nebulization inhalation therapy on sputum viscosity and oxygen metabolism in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 120 AECOPD patients admitted to our hospital from July 2021 to October 2023 were included and randomly divided into western medicine group and combination group by random number table method,with 60 cases in each group.The western medicine group was given acetylcysteine nebulization inhalation on the basis of conventional treatment,while the combination group was given oral administration of Mashe Anjin pill based on western medicine group.Both groups received continuous treatment for 14 days.The changes in sputum viscosity,blood gas analysis indexes[partial pressure of carbon dioxide(PaCO_(2)),arterial oxygen pressure(PaO_(2))and oxygen saturation(SaO_(2))],pulmonary ventilation function indicators[forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1))and FEV_(1)/FVC]in both groups were measured and recorded before and after treatment,and the clinical efficacy of each group was observed and compared.Results After treatment,the total effective rate of the western medicine group was lower than the combination group(75.00%vs 93.33%,P<0.05).The viscosity of sputum in both groups improved,and the improvement degree in the combination group was obviously better than that in the western medicine group(P<0.05).After treatment,the SaO_(2) and PaO_(2) in both groups were increased than before treatment(P<0.05),while the PaCO_(2) was decreased(P<0.05),and the SaO_(2) and PaO_(2) in the combination group were higher than the western medicine group(P<0.05),while the PaCO_(2) was lower than the western medicine group(P<0.05).After treatment,the FVC,FEV_(1),and FEV_(1)/FVC of both groups were increased than before treatment(P<0.05),and the combination group were higher than the western medicine group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Mashe Anjin pill and acetylcysteine nebulization inhalation can effectively reduce sputum viscosity,improve oxygen metabolism and lung ventilation function,and improve clinical efficacy in AECOPD patients.
作者
张胜男
邓敬华
王玉栋
ZHANG Shengnan;DENG Jinghua;WANG Yudong(Department of Pulmonary Disease,Hengshui Hospital of Traditional Chinese Medicine,Hengshui 053000,Hebei Province,China)
出处
《世界临床药物》
CAS
2024年第9期919-924,930,共7页
World Clinical Drug
基金
河北省中医药管理局科研计划项目(2022274)。
关键词
麻射安金丸
乙酰半胱氨酸
慢性阻塞性肺疾病急性加重期
氧代谢
肺功能
痰液黏稠度
Mashe Anjin pill
acetylcysteine
acute exacerbation of chronic obstructive pulmonary disease
oxygen metabolism
lung function
sputum viscosity
