摘要
目的镜像神经元疗法对中风后复杂性区域疼痛综合征(CRPS)Ⅰ期的临床疗效及作用机制的探讨。方法选择康复科收治的40例CRPSⅠ期患者为研究对象。在研究中采用随机法,将选择的40例患者分为对照组与镜像组,每组20例。均采取基础以及常规康复治疗,镜像组额外追加镜像治疗,两组每天上下午各治疗1次,5次/周,共治疗3周。采用休息状态视觉模拟评分(resting state visual analogue scale,R-VAS)与被动运动视觉模拟评分(passive movement state visual analogue scale,P-VAS)来评估上肢肩关节疼痛状况,选择运用排水法来评估手部肿胀状况,并且选择运用Fugl-Meyer量表,评估上肢运动功能,采用ELISA检测技术进行测定血清降钙素基因相关肽(CGRP)、P物质(SP)含量。结果镜像组患者治疗3周后的肩关节R-VAS、P-VAS评分及肿胀程度均低于对照组(P<0.05),Fugl-Meyer评分高于对照组(P<0.05),SP含量低于对照组(P<0.05),CGRP含量高于对照组(P<0.05)。结论镜像组能更有效地改善CRPSⅠ期患者肩关节疼痛、手部肿胀及上肢功能障碍,调节血清CGRP及SP细胞水平。
Objective To explore the clinical efficacy and mechanism of mirror neuron therapy in the treatment of phaseⅠcomplex regional pain syndrome(CRPS)following stroke.Methods A total of 40 patients with CRPS phaseⅠwere selected from the Rehabilitation Department for this study.The patients were randomly divided into a control group and a mirror therapy group,with 20 patients in each group.Both groups received basic and conventional rehabilitation treatments,while the mirror therapy group additionally received mirror therapy.Treatment was administered twice daily,five times per week,for three weeks.Pain in the shoulder joint was evaluated using the Resting State Visual Analogue Scale(R-VAS)and the Passive Movement State Visual Analogue Scale(P-VAS).Hand swelling was assessed using the water displacement method,and upper limb motor function was evaluated with the Fugl-Meyer scale.Serum levels of calcitonin gene-related peptide(CGRP)and substance P(SP)were measured using ELISA.Results After three weeks of treatment,patients in the mirror therapy group showed lower R-VAS and P-VAS scores,reduced hand swelling,and higher Fugl-Meyer scores compared to the control group(P<0.05).Additionally,the mirror therapy group had lower serum SP levels and higher CGRP levels than the control group(P<0.05).Conclusion Mirror therapy is more effective in alleviating shoulder joint pain,hand swelling,and upper limb dysfunction in CRPS phaseⅠpatients,and it regulates serum CGRP and SP levels.
作者
宋宇锦
张伟
温红娟
王静
张裴景
冯慧利
王慧灵
常译牛
任彬彬
SONG Yu-jin;ZHANG Wei;WEN Hong-juan;WANG Jing;ZHANG Pei-jing;FENG Hui-li;WANG Hui-ling;CHANG Yi-niu;REN Bin-bin(Rehabilitation Center,First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450099,Henan,China;不详)
出处
《广东医学》
CAS
2024年第9期1137-1142,共6页
Guangdong Medical Journal
基金
河南省中医药科学研究专项课题(2021ZY2182,2019JDZX2111,2019JDZX2016)
河南省中医药拔尖人才培养项目专题课题项目(2022ZYBJ09)。
