摘要
目的:基于CT血管造影(CCTA)探讨血浆致动脉粥样硬化指数(AIP)与冠状动脉CT易损斑块的关系。方法:回顾性收集2021年1月至2024年2月沈阳医学院附属第二医院行CCTA检查的213例冠心病(CHD)患者资料,根据是否存在冠状动脉易损斑块将其分为易损斑块组(123例)和非易损斑块组(90例)。收集患者年龄、性别、吸烟史、饮酒史、糖尿病史等一般临床资料及AIP等血清指标,比较两组AIP及其他血清指标的差异,通过多因素logistic回归分析确定冠状动脉易损斑块的独立影响因素,并绘制受试者工作特征(ROC)曲线,评估AIP对易损斑块的预测价值。结果:易损斑块组AIP为0.22±0.31,高于非易损斑块组的0.05±0.27,两组比较差异有统计学意义(t=4.223,P<0.001),多因素logistic分析显示,多因素logistic回归AIP与CT易损斑块独立相关(OR=7.556,95%CI:2.442~23.385,P=0.002)。ROC曲线显示,AIP预测CT易损斑块的最佳截断值为0.20,ROC曲线下面积为0.665,灵敏度为55.56%,特异度为73.98%。结论:AIP是CHD患者合并易损斑块的独立影响因素,且对易损斑块有一定的预测价值。
Objective:To explore the relationship between atherosclerotic index of plasma(AIP)and vulnerable plaque of coronary under computed tomography(CT)based on coronary CT angiography(CCTA).Methods:Data were retrospectively collected on 213 patients with coronary heart disease(CHD)who underwent CCTA examination from January 2021 to February 2024 at the Second Affiliated Hospital of Shenyang Medical College,and they were divided into a vulnerable plaque group(123 cases)and a non-vulnerable plaque group(90 cases)according to whether existed vulnerable plaque of coronary artery.General clinical data such as age,gender,history of smoking,history of alcohol consumption,history of diabetes,and serum indicators such as AIP were collected.The differences in AIP and other factors between the two groups were compared.The independent influencing factors of vulnerable plaque of coronary artery were determined by multifactorial logistic regression analysis,and the predictive value of AIP for vulnerable plaque was assessed by drawing a receiver operating characteristic(ROC)curve.Results:AIP of vulnerable plaque group was 0.22±0.31,which was higher than that 0.05±0.27 of the vulnerable plaque group,and the difference of AIP between two groups was significant(t=4.223,P<0.001).Multifactorial logistic analysis showed there was independent correlation between AIP and vulnerable plaque under CT(OR=7.556,95%CI:2.442~23.385,P=0.002).The ROC curve showed that the best cut-off value of AIP was 0.20 in predicting vulnerable plaque under CT,and the value of area under curve(AUC)was 0.665,and the sensitivity was 55.56%and the specificity was 73.98%.Conclusion:AIP is an independent influencing factor for CHD patients who complicate vulnerable plaques,and it has a certain of predictive value for vulnerable plaques.
作者
周暄凯
韩晓雯
王冠
朱治
赵树昕
崔凡
施嘉航
朴成浩
Zhou Xuankai;Han Xiaowen;Wang Guan;Zhu Zhi;Zhao Shuxin;Cui Fan;Shi Jiahang;Piao Chenghao(Department of Radiology,The Second Affiliated Hospital of Shenyang Medical College,Shenyang 110035,China;CT Products Division,Neusoft Medical Systems Co.,Ltd.,Shenyang 110035,China;Medical Imaging Centre,Shunde Hospital,Guangzhou University of Chinese Medicine,Foshan 528300,China)
出处
《中国医学装备》
2024年第10期46-50,共5页
China Medical Equipment
