摘要
目的分析粤东地区人群血液不规则抗体检测结果,研究该地区人群具有临床意义的红细胞血型抗原分布频率,为粤东地区的血站和医院提供有价值的血液储备参考意见。方法以2012—2021年在汕头市中心医院进行不规则抗体筛查的患者作为研究对象,采用凝胶抗人球蛋白法对不规则抗体筛查结果为阳性的患者进行抗体鉴定。结果在61036例抗体筛查患者中鉴定出特异性抗体108例,其中抗-E有51例(占47.22%)、抗-D有19例(占17.59%)、抗-c有10例(占9.26%)、抗-e有9例(占8.33%)、抗-C有5例(占4.63%)、抗-Lea有4例(占3.70%)、抗-Jkb有4例(占3.70%)、抗-S有3例(占2.79%)、抗-M有2例(占1.85%)、抗-s有1例(占0.93%)。不同科室不规则抗体筛查阳性率比较差异有统计学意义,其中新生儿科的阳性检出率最高,为1.88%;妇产科的阳性例数最多,检出82例。既往有妊娠史的女性患者不规则抗体阳性率显著高于无妊娠史女性,差异有统计学意义(0.77%比0.43%,P<0.05);有输血史患者的不规则抗体阳性率显著高于无输血史的患者(0.60%比0.43%,P<0.05)。结论粤东地区人群抗-E抗体的检出率最高,不同科室抗筛阳性率不同,且妊娠史和输血史均与不规则抗体的产生有关,可针对常见抗体以及“特殊”患者提早储备相应抗原的血液,保障输血安全。
Objective To analyze the detection results of blood irregular antibodies of the population in eastern Guangdong,study the distribution frequency of clinically significants blood group antigens of red blood cells in the population in this region,and provide valuable blood reserve reference opinions for blood stations and hospitals in eastern Guangdong.Methods The patients who underwent irregular antibody screening in Shantou Central Hospital from 2012 to 2021 were selected as research subjects,and gel anti-globulin method was used to identify the antibodies in patients with positive irregular antibody screening.Results The 108 cases of specific antibodies were identified among 61036 patients with antibody screening,including 51 cases of anti-E(accounting for 47.22%),19 cases of anti-D(accounting for 17.59%),10 cases of anti-c(accounting for 9.26%),9 cases of anti-e(accounting for 8.33%),5 cases of anti-C(accounting for 4.63%),4 cases of anti-Lea(accounting for 3.70%),4 cases of anti-Jkb(accounting for 3.70%),3 cases of anti-S(accounting for 2.79%),2 cases of anti-M(accounting for 1.85%)and 1 case of anti-s(accounting for 0.93%).There was a statistically significant difference in the positive rates of irregular antibody screening in different departments.Among them,the positive detectable rate in department of neonatology was the highest,which was 1.88%.The department of obstetrics and gynecology had the highest number of positive cases,with 82 cases detected.The positive rate of irregular antibody in female patients with history of pregnancy was higher than that of patients without history of pregnancy(0.77%vs.0.43%,P<0.05).The positive rate of irregular antibodies in patients with history of blood transfusion was higher than that in patients without history of blood transfusion(0.60%vs.0.43%,P<0.05).Conclusions The detectable rate of anti-E in the population in eastern Guangdong is the highest.The positive rates of antibody screening are different in different departments.Moreover,pregnancy history and blood transfusion history are related to the production of irregular antibodies.It is possible to reserve blood in advance for common antibodies and"special"patients and ensure the safety of blood transfusion.
作者
黄德喜
肖遥
黄美淦
Huang Dexi;Xiao Yao;Huang Meigan(Department of Blood Transfusion,Shantou Central Hospital,Shantou 515000,Guangdong,China)
出处
《实用检验医师杂志》
2024年第3期261-265,共5页
Chinese Journal of Clinical Pathologist
基金
广东省汕头市科技计划医疗卫生类别项目(汕府科[2021]-114号-15)。
关键词
不规则抗体筛查
影响因素
血液储备
Irregular antibody screening
Influencing factor
Blood reserve
