摘要
SOX10(SRY-box 10)属于SOX(SRY-related HMG-box)转录因子家族,该家族以能介导Sox蛋白与DNA结合的HMG(high mobility group)盒子为特征。神经嵴细胞(neural crest cells,NCCs)是可迁移的多能细胞,在其整个发育过程中分化成许多细胞类型,包括内耳的前庭耳蜗神经胶质细胞、神经系统的胶质细胞、皮肤的黑色素细胞、颅面复合体的骨骼和结缔组织细胞及心血管的平滑肌细胞等。SOX10是NCCs的多能性的维持和神经嵴衍生细胞的生存所必需的。SOX10基因通过参与神经嵴衍生细胞的发育以多种途径对内耳发育进行调控,本文将已有SOX10对神经嵴衍生细胞发育中所起作用的相关文献进行梳理做一综述,以期更深一步了解SOX10基因在内耳发育中的调控机制,从而能够对SOX10突变所致综合征型耳聋做出更好的干预。
The SOX10(SRY-box 10)gene belongs to the SOX(SRY-related HMG-box)transcription factor family,and is characterized by HMG(high mobility group)boxes that mediate the binding of Sox proteins to DNA.Neural crest cells(NCCs)are migratory pluripotent cells that differentiate into many cell types throughout their development,including vestibular cochlear glial cells in the inner ear,glial cells of the nervous system,melanocytes in the skin,bone and connective tissue cells in the craniofacial complex,and smooth muscle cells in the cardiovascular system.The SOX10 is necessary for the maintenance of the pluripotency of NCCs and the survival of neural crest-derived cells.The SOX10 gene regulates inner ear development in a variety of ways by participating in the development of neural crest-derived cells.This paper reviews relevant literatures on the roles of SOX10 in the development of neural crest-derived cells,in order to further understand its regulatory mechanisms in inner ear development,so as to better intervene in syndromic deafness caused by SOX10 mutations.
作者
赵亚楠
庞秀红
ZHAO Yanan;PANG Xiuhong(Dalian Medical University,Dalian 116000,China;不详)
出处
《中华耳科学杂志》
CSCD
北大核心
2024年第4期679-683,共5页
Chinese Journal of Otology
基金
江苏省卫生健康委科研课题(M2022067)
泰州市科技支撑(社会发展)项目(TS202214)
国家自然科学基金青年基金(81700920)
江苏省基础研究计划(自然科学基金)面上项目(BK20191229)
江苏省第五期“333工程”科研项目(BRA2019192)。
关键词
SOX10基因
神经嵴衍生细胞
内耳发育
调控机制
SOX10 gene
neural crest-derived cells
inner ear development
governance mechanism
