摘要
目的分析N末端脑钠肽前体(N-terminal pro-brain natriuretic peptide,NT-proBNP)在评估心力衰竭患者预后评估中的价值。方法纳入2023年1月到2024年1月于肥城市人民医院就诊的80例心力衰竭患者,根据患者预后分为预后良好组(A组,n=48例)和预后较差组(B组,n=32例)。比较两组研究对象的基础资料、心肌损伤指标、心功能指标,并分析心功能指标与心肌损伤指标的相关性及心肌损伤指标对心力衰竭预后的评估价值。结果两组患者在性别、年龄、BMI、吸烟史、饮酒史、是否伴糖尿病上均无显著差异(P>0.05);预后良好组伴高血压的概率低于B组,差异有统计学意义(P=0.001)。预后良好组心肌损伤相关指标NT-proBNP、TnI、hs-CRP均显著低于预后较差组(P值均<0.001)。预后良好组患者心功能指标LVEF(%)、E/A均显著高于预后较差组(P值均<0.001)。LVEF与NT-proBNP、TnI、hs-CRP均呈负相关(P<0.001)。NT-proBNP、TnI、hs-CRP对心力衰竭患者的预后评估价值均较高,且NT-proBNP的准确性高于TnI、hs-CRP。结论NT-proBNP水平的高低可一定程度上揭示心力衰竭患者疾病的具体状态,还能够预测心力衰竭患者的预后。
Objective To analyze the value of N-terminal pro-brain natriuretic peptide(NT-proBNP)in evaluating the prognosis of patients with heart failure.Methods 80 patients with heart failure who were treated at Feicheng People's Hospital from January 2023 to January 2024 were included in the study.They were divided into a good prognosis group(group A,n=48)and a poor prognosis group(group B,n=32)based on their prognosis.Compare the basic data,myocardial injury indicators,and cardiac function indicators of the two groups of subjects,and analyze the correlation between cardiac function indicators and myocardial injury indicators,as well as the prognostic value of myocardial injury indicators for heart failure.Results There were no significant differences in gender,age,BMI,smoking history,alcohol consumption history,and diabetes status between the two groups(P>0.05);The probability of hypertension in the group with a favorable prognosis was lower than that in group B,and the difference was statistically significant(P=0.001).The myocardial injury-related indicators NT-proBNP,TnI,and hs-CRP in the group with a favorable prognosis were significantly lower than those in the group with a poor prognosis(Pvalues<0.001 for all).The cardiac function indicators LVEF(%)and E/A in the group with a favorable prognosis were significantly higher than those in the group with a poor prognosis(Pvalues<0.001 for all).LVEF was negatively correlated with NT-proBNP,TnI,and hs-CRP(P<0.001).The prognostic evaluation value of NT-proBNP,TnI,and hs-CRP for patients with heart failure is high,and the accuracy of NT-proBNP is higher than that of TnI and hs-CRP.Conclusion The level of NT-proBNP can reveal the specific state of heart failure patients to a certain extent,and can also predict the prognosis of heart failure patients.
作者
李玲
LI Ling(Feicheng People's Hospital Internal Medicine-Cardiovascular Department,Feicheng 271600,China)
出处
《中华灾害救援医学》
2024年第8期957-960,共4页
Chinese Journal of Disaster Medicine
关键词
心力衰竭
N末端脑钠肽前体
预后
heart failure
N-terminal pro-brain natriuretic peptide
prognosis
