摘要
目的探讨超声引导下细针穿刺(FNA)细胞学、鼠类肉瘤病毒癌基因同源物B(BRAF)V600E基因突变单独及联合检测对甲状腺癌的诊断价值。方法选取127例甲状腺结节患者,均接受超声引导下FNA细胞学、BRAF V600E基因突变检测,以病理检查结果为金标准,评估FNA细胞学、BRAF V600E基因突变单独及联合检测对甲状腺癌的诊断价值;采用Kappa检验评估FNA细胞学、BRAF V600E基因突变单独及联合检测诊断甲状腺癌的结果与病理检查结果的一致性。结果FNA细胞学、BRAF V600E基因突变联合检测诊断甲状腺癌的灵敏度为98.06%,特异度为100%,准确度为98.43%,阳性预测值为100%,阴性预测值为92.31%,均高于二者单独检测。FNA细胞学、BRAF V600E基因突变联合检测诊断甲状腺癌的结果与病理检查结果的一致性极高(Kappa=0.950),高于BRAF V600E基因突变(Kappa=0.877)和FNA细胞学(Kappa=0.772)单独检测。病理检查结果显示,阳性(甲状腺癌)103例,阴性24例,分别作为恶性组和良性组。恶性组患者FNA细胞学检测评分明显高于良性组,BRAF V600E基因突变检测CT值明显低于良性组,差异均有统计学意义(P﹤0.01)。结论FNA细胞学、BRAF V600E基因突变联合检测对甲状腺癌具有较高的诊断价值。
Objective To explore the diagnostic value of ultrasound-guided fine-needle aspiration(FNA)cytology,vraf murine sarcoma viral oncogene homolog B(BRAF)V600E gene mutation single and combined detection for thyroid cancer.Method A total of 127 patients with thyroid nodules were selected and underwent ultrasound-guided FNA cytology and BRAF V600E gene mutation detection.Pathological examination result was used as the gold standard,the diagnostic value of FNA cytology and BRAF V600E gene mutation single and combined detection for thyroid cancer were evaluated.The Kappa test was used to evaluate the consistency between the results of FNA cytology and BRAF V600E gene mutation single and combined detection for the diagnosis of thyroid cancer and the pathological examination results.Result The sensitivity of FNA cytology and BRAF V600E gene mutation combined detection for the diagnosis of thyroid cancer was 98.06%,specificity was 100%,accuracy was 98.43%,positive predictive value was 100%,and negative predictive value was 92.31%,which were higher than those of the single detection.The consistency between the results of FNA cytology and BRAF V600E gene mutation combined detection in diagnosing thyroid cancer and pathological examination was extremely high(Kappa=0.950),which was higher than those of BRAF V600E gene mutation detection(Kappa=0.877)and FNA cytology detection(Kappa=0.772),respectively.Pathological examination results showed that 103 cases were positive(thyroid cancer)and 24 cases were negative,which were classified as malignant group and benign group,respectively.The FNA cytology score of malignant group was significantly higher than that of benign group,and the CT value of BRAF V600E gene mutation detection was significantly lower than that of benign group,the differences were statistically significant(P<0.01).Conclusion The FNA cytology and BRAF V600E gene mutation combined detection has high diagnostic value for thyroid cancer.
作者
王明军
薛源
乔楠
乔乐乐
刘九洲
任宁
程维刚
WANG Mingjun;XUE Yuan;QIAO Nan;QIAO Lele;LIU Jiuzhou;REN Ning;CHENG Weigang(Department of Thyroid Head and Neck Tumor Surgery,Clinical Medicine School of He’nan University of Science and Technology/the First Affiliated Hospital of He’nan University of Science and Technology,Luoyang 471003,He’nan,China)
出处
《癌症进展》
2024年第17期1952-1955,共4页
Oncology Progress
关键词
甲状腺癌
细针穿刺细胞学
鼠类肉瘤病毒癌基因同源物B
基因突变
thyroid cancer
fine-needle aspiration cytology
v-raf murine sarcoma viral oncogene homolog B
gene mutation
