摘要
越来越多的研究显示,自主神经系统在各种癌症的发展中扮演着至关重要的角色。肿瘤细胞通过分泌包括神经营养因子、趋化因子、神经细胞黏附分子、轴突导向分子在内的多种神经活性分子改变肿瘤微环境,并将其周围的自主神经招募到肿瘤,或者重编程交感神经、促进神经祖细胞迁移到瘤内分化为交感神经从而增加自主神经支配。此外,肿瘤还可通过外泌体作用于神经纤维,促进周围神经浸润。肿瘤微环境中各种物质之间的相互作用为周围神经浸润的发生创造了合适的环境。在这个过程中,交感神经促进癌症进展并通过提高化疗耐药性为抗肿瘤治疗带来挑战,而副交感神经不仅具有促肿瘤作用,还表现出抗肿瘤特性。因此文章主要综述了癌症和自主神经之间的相互作用,以及神经活性分子在癌症进展中的作用,并提出了潜在的神经系统相关的抗肿瘤治疗策略。
More and more studies have shown that the autonomic nervous system plays a crucial role in the development of various cancers.Cancer cells secrete various neuroactive molecules,including neurotrophic factors,chemokines,neural cell adhesion molecules,and axon guidance molecules,to alter the tumor microenvironment and recruit surrounding autonomic nerves to the tumor tossies.Alternatively,cancer cells reprogram sympathetic nerves or promote the migration of neural progenitor cells into the tumor tissues to differentiate into sympathetic nerves,thus increasing autonomic innervation.Moreover,cancer cells act on nerve fibers through exosomes,promoting peripheral nerve infiltration.The interactions among various substances in the tumor microenvironment create a suitable environment for the occurrence of perineural infiltration.During this process,the sympathetic nervous system promotes cancer progression and poses challenges to antitumor therapy by enhancing chemotherapy resistance.In contrast,the parasympathetic nervous system exhibits both tumor-promoting and antitumor properties.Therefore,this review primarily summarizes the interactions between cancer and the autonomic nervous system,as well as the role of neuroactive molecules in cancer progression,and proposes potential nervous system-related antitumor treatment strategies.
作者
李飞阳
许鹏飞
李大可
LI Feiyang;XU Pengfei;LI Dake(Department of Gynecology,Women’s Hospital of Nanjing Medical University(Nanjing Women and Children’s Healthcare Hospital),Nanjing 210004,China)
出处
《南京医科大学学报（自然科学版）》
CAS
北大核心
2024年第10期1408-1418,共11页
Journal of Nanjing Medical University(Natural Sciences)
基金
国家自然科学基金(81872379,82272692)。
关键词
交感神经
副交感神经
周围神经浸润
肿瘤微环境
sympathetic nerve
parasympathetic nerve
peripheral nerve infiltration
tumor microenvironment
