摘要
肠易激综合征(irritable bowel syndrome,IBS)是临床上常见的肠道功能性紊乱的疾病,发病机制复杂,目前尚未十分明确,且发病率逐年上升,严重影响患者生存质量及工作效率。西医常规治疗手段以抗痉挛,止泻,抗抑郁等为主,但疗效欠佳,症状迁延难愈。中医药治疗疾病在辨证论治基础上,注重整体观念,标本同治。中医药可通过作用于信号通路治疗IBS,与西医治疗相比,中医药治疗具有多层次,多环节,多靶点的优势。文章通过查阅国内外文献,对近年来相关文献疏理,整理出NF-κB/AKT-STAT/TRPV1/5-HT/MAPK/MicroRNAs相关信号通路,期望为中医药治疗IBS提供新的思路。
Irritable bowel syndrome(IBS)is a common disease of intestinal functional disorder in clinic,the pathogenesis is complex and has not been very clear at present,and the incidence of IBS is increasing year by year,which seriously affects the quality of life and work efficiency of patients.The routine treatment of western medicine is mainly antispasmodic,antidiarrhea,antidepressant and so on,but the curative effect is not good and the symptoms are difficult to heal.Traditional Chinese medicine in the treatment of diseases on the basis of dialectical treatment,pay attention to the overall concept,specimen treatment.A large number of studies have shown that traditional Chinese medicine can act on signal pathway to treat IBS.Compared with western medicine,traditional Chinese medicine has the advantages of multi-level,multi-link and multi-target.By consulting the literature at home and abroad,the author collates the NF-κB/AKT-STAT/TRPV1/5-HT/MAPK/MicroRNAs related signal pathway in recent years,hoping to provide a new way of thinking for the treatment of IBS with traditional Chinese medicine.
作者
陈小霞
黄适
谢璐安
张扬雨
潘震东
CHEN Xiaoxia;HUANG Shi;XIE Luan;ZHANG Yangyu;PAN Zhendong(Guangxi University of Chinese Medicine,Nanning 530001,Guangxi,China;Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530001,Guangxi,China)
出处
《实用中医内科杂志》
2024年第9期4-7,共4页
Journal of Practical Traditional Chinese Internal Medicine
基金
国家自然科学基金项目(82060845)
广西中医药大学双一流项目(0S019018H5)。
关键词
中医药
肠易激综合征
信号通路
研究进展
traditional Chinese medicine
irritable bowel syndrome
signal pathway
research progress
