摘要
目的系统评价香砂六君子汤联合化疗治疗中晚期胃癌的安全性和疗效性,并通过GRADE质量评价分析证据等级。方法检索中国知网、万方数据知识服务平台、维普中文科技期刊数据库(中文科技期刊数据库)、PubMed、Cochrane Library、Web of Science数据库建库至2023年7月发表的文章,利用EndNote X9、Review Manager 5.3软件进行文献筛选与剔除、meta分析。结果共纳入18篇文献,研究例数共1430例,其中研究组717例,对照组713例。meta分析结果显示,香砂六君子汤联合化疗可以提高肿瘤治疗有效率(OR=2.17,95%CI:1.65~2.85,P<0.00001)、中医症候评分(OR=4.89,95%CI:2.40~9.98,P<0.0001)及生活质量(MD=6.40,95%CI:4.19~8.60,P<0.00001),减少恶性呕吐(OR=0.14,95%CI:0.08~0.24,P<0.0001)和白细胞减少的发生数(OR=0.35,95%CI:0.17~0.72,P=0.005),主要是减少Ⅲ~Ⅳ级的白细胞减少发生数(OR=0.22,95%CI:0.12~0.38,P<0.00001),但对腹泻(OR=0.31,95%CI:0.09~0.32,P<0.00001)的meta分析有统计学意义,但无显著性差异。结论香砂六君子汤联合化疗可以提高晚期胃癌治疗的效果,减少不良反应的发生,给临床治疗胃癌提供了理论依据。
Objective To systematically evaluate the safety and efficacy of Xiangsha Liujunzi Decoction combined with chemotherapy in the treatment of advanced gastric cancer,so as to analyze the evidence level through GRADE quality evaluation.Methods The literatures published in China National Know ledge Int ernet,Wa nfang Dat a Kno wledge Se rvice Pl atform,China Sci ence a nd Tec hnology Journal Database,PubMed,Cochrane Library and Web of Science database from establishment to July 2023 were searched,and literature screening and elimination and Meta-analysis were conducted by using EndNote X9 and Review Manager 5.3.Results A total of 18 literatures containing 1430 research cases were included,and they were divided into the study group(n=717)and the control group(n=713).The Meta-analysis results showed that the combination of Xiangsha Liujunzi Decoction and chemotherapy could improve the tumor’s overall response rate(OR=2.17,95%CI:1.65-2.85,P<0.00001)and the TCM symptom score(OR=4.89,95%CI:2.40-9.98,P<0.0001),and the quality of life(MD=6.40,95%CI:4.19-8.60,P<0.00001).The incidences of malignant vomiting(OR=0.14,95%CI:0.08-0.24,P<0.0001)and leukopenia(OR=0.35,95%CI:0.17-0.72,P=0.005)were reduced,mainly in the incidence of gradeⅢ-Ⅳleukopenia(OR=0.22,95%CI:0.12-0.38,P<0.00001).However,there was statistical significance in the Meta-analysis of abdominal diarrhea(OR=0.31,95%CI:0.09-0.32,P<0.00001),but without remarkable difference.Conclusion Xiangsha Liujunzi Decoction combined with chemotherapy can improve the therapeutic efficacy of advanced gastric cancer and reduce the occurrence of adverse reactions,which provides a theoretical basis for clinical t reatment of gastric cancer.
作者
龙文婷
戴娟
卓德斌
LONG Wenting;DAI Juan;ZHUO Debin(Graduate School,Hunan University of Chinese Medicine,Hunan,Changsha 410000,China;Chinese Medicine Specialty Diagnostic and Treatment Center,Hunan Province Directly Affiliated Traditional Chinese Medicine Hospital,Hunan,Zhuzhou 412000,China;DepartmentⅢof Oncology,Hunan Province Directly Affiliated Traditional Chinese Medicine Hospital,Hunan,Zhuzhou 412000,China)
出处
《中国医药科学》
2024年第17期134-138,194,共6页
China Medicine And Pharmacy
基金
2022年戴娟全国名老中医药专家传承工作室(湘财社指〔2022〕29号)。
