摘要
目的探讨人免疫球蛋白联合头孢哌酮钠舒巴坦钠治疗新生儿肺炎的疗效。方法随机选取2021年9月—2022年9月厦门市第三医院新生儿科收治的90例新生儿肺炎患儿为研究对象,按不同治疗方法将其分为两组,对照组(45例)予以头孢哌酮钠舒巴坦钠治疗;观察组(45例)予以头孢哌酮钠舒巴坦钠联合人免疫球蛋白治疗。比较两组的临床疗效、免疫球蛋白水平、炎症因子水平及不良反应总发生率。结果观察组治疗总有效率为95.55%(43/45),高于对照组的68.89%(31/45),差异有统计学意义(χ^(2)=10.946,P<0.05);治疗后,观察组的免疫球蛋白G、免疫球蛋白M、免疫球蛋白A水平均高于对照组,炎性因子水平低于对照组,差异有统计学意义(P均<0.05)。观察组的不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论人免疫球蛋白联合头孢哌酮钠舒巴坦钠治疗新生儿肺炎,可提高治疗有效率,增强患儿机体免疫力。
Objective To investigate the efficacy of human immunoglobulin combined with cefoperazone sodium and sulbactam sodium in the treatment of neonatal pneumonia.Methods A total of 90 children with neonatal pneumonia admitted to the Neonatology Department of Xiamen Third Hospital from September 2021 to September 2022 were ran-domly selected as the research objects.They were divided into two groups according to different treatment methods.The control group(45 cases)was treated with cefoperazone sodium and sulbactam sodium.The observation group(45 cases)was treated with cefoperazone sodium and sulbactam sodium combined with human immunoglobulin.The clini-cal efficacy,immunoglobulin level,inflammatory factor level and the total incidence of adverse reactions were com-pared between the two groups.Results The total effective rate of treatment in the observation group was 95.55%(43/45),which was higher than 68.89%(31/45)in the control group,and the difference was statistically significant(χ^(2)=10.946,P<0.05).After treatment,the levels of immunoglobulin G,immunoglobulin M and immunoglobulin A in the observation group were all higher than those in the control group,and the levels of inflammatory factors were lower than those in the control group,the differences were statistically significant(all P<0.05).The incidence of adverse re-actions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Human immunoglobulin combined with cefoperazone sodium and sulbactam sodium in the treat-ment of neonatal pneumonia can improve the effective rate of treatment and enhance the immunity of children.
作者
林亚娥
何海强
黄文婷
潘丽芬
LIN Ya'e;HE Haiqiang;HUANG Wenting;PAN Lifen(Department of Neonatology,The First Affiliated Hospital of Xiamen University(Xiamen Third Hospital)Tong'an Campus,Xiamen 361024,Fujian,China;Operation Room,Fuzhou Hospital of Traditional Chinese Medicine,Fuzhou 350000,Fujian,China)
出处
《中外医疗》
2024年第23期120-123,共4页
China & Foreign Medical Treatment
关键词
新生儿肺炎
人免疫球蛋白
头孢哌酮钠舒巴坦钠
Neonatal pneumonia
Human immunoglobulin
Cefoperazone sodium and sulbactam sodium
