摘要
目的:探讨核磁共振成像(MRI)联合血清血小板活化因子(PAF)、可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)在诊断脑梗死中的临床应用价值。方法:选择2021年10月~2022年10月期间在本院就诊的疑似脑梗死患者130例作为研究对象。经临床及影像学确诊为73例脑梗死患者作为脑梗死组,其余排除脑梗死的57例患者作为对照组。所有患者均行MRI检测;ELISA法检测血清PAF、sTWEAK表达水平;ROC曲线分析MRI联合血清PAF、sTWEAK对脑梗死的诊断价值。结果:MRI检查可见脑梗死的区域呈斑片状或者片状的异常信号,T1WI序列呈等信号或稍低信号,T2WI高信号,T2WI、FLAIR序列稍高信号,DWI呈高信号,ADC图呈低信号。在73例脑梗死中,MRI检查出脑梗死62例,MRI诊断脑梗死的灵敏度为84.93%、特异度87.72%,准确度为86.15%。与对照组比较,脑梗死组患者血清PAF、sTWEAK水平升高(P<0.05)。不同病情严重程度脑梗死患者血清PAF、sTWEAK水平比较差异有统计学意义(P<0.05)。MRI联合血清PAF、sTWEAK诊断脑梗死的AUC为0.970,联合诊断效能高于MRI、PAF、sTWEAK单独检测(P<0.05)。结论:MRI联合血清PAF、sTWEAK对脑梗死具有一定诊断价值,可为脑梗死的临床诊治提供参考。
Objective:To investigate the clinical value of magnetic resonance imaging(MRI)combined with serum platelet activating factor(PAF)and soluble tumor necrosis factor-like weak apoptosis-inducing factor(sTWEAK)in the diagnosis of cerebral infarction.Methods:130 patients with suspected cerebral infarction who were treated in our hospital from October 2021 to October 2022 were selected as the study objects.73 patients with cerebral infarction were clinically and radiologically confirmed as the cerebral infarction group,and the remaining 57 patients with cerebral infarction were excluded as the control group.MRI was performed in all patients.The expression levels of serum PAF and sTWEAK were detected by ELISA.The diagnostic value of MRI combined with serum PAF and sTWEAK in cerebral infarction was analyzed by ROC curve.Results:MRI showed patchy or patchy abnormal signals in the cerebral infarction area,equal signal or slightly low signal in T1WI,high signal in T2WI,slightly high signal in T2WI and FLAIR,high signal in DWI,and low signal in ADC.Among the 73 cases of cerebral infarction,MRI detected 62 cases of cerebral infarction.The sensitivity,specificity and accuracy of MRI diagnosis were 84.93%,87.72%and 86.15%.Compared with control group,serum PAF and sTWEAK levels in cerebral infarction group were increased(P<0.05).There were significant differences in serum PAF and sTWEAK levels in patients with different severity of cerebral infarction(P<0.05).The AUC of MRI combined with serum PAF and sTWEAK in the diagnosis of cerebral infarction was 0.970,which was higher than that of MRI combined with serum PAF and sTWEAK alone(P<0.05).Conclusion:MRI combined with serum PAF and sTWEAK has certain diagnostic value for cerebral infarction,and can provide reference for clinical diagnosis and treatment of cerebral infarction.
作者
张书佳
陈磊
张尧智
Zhang Shu-jia;Chen Lei;Zhang Yao-zhi(CT Room,Xiping People's Hospital,Zhumadian 463900,Henan,China)
关键词
核磁共振成像
血小板活化因子
可溶性肿瘤坏死因子样凋亡弱诱导因子
脑梗死
诊断
Nuclear magnetic resonance imaging
Platelet activating factor
Soluble tumor necrosis factor-like weak inducer of apoptosis
Cerebral infarction
Diagnosis
