摘要
甲状腺癌发病与环境因素密切相关,环境变化导致的基因突变和腺体组织分子生物学改变是诱发甲状腺癌的重要因素之一。尽管甲状腺癌的相关分子机制仍未完全阐明,但随着分子生物学技术的发展,越来越多的甲状腺癌特定遗传改变和分子标志物被挖掘出来。本文就甲状腺癌的病因、特异性分子标志物、诊断及靶向治疗研究进展进行综述,为甲状腺癌的临床诊疗提供理论支持。
Thyroid carcinoma is closely related to environmental factors.Gene mutations and molecular biological changes of gland tissue caused by environmental changes are important factors inducing thyroid carcinoma.Although the molecular mechanism of thyroid carcinoma has not been fully elucidated,increasingly specific genetic changes and molecular markers for thyroid carcinoma have been discovered with the development of molecular biology techniques.This article reviews the recent progresses on the etiology,specific molecular markers,diagnosis and targeted therapies of thyroid carcinoma,so as to provide theoretical support for the clinical diagnosis and treatment of thyroid carcinoma.
作者
滕伟强
王秋阳
马毅
张才云
郑宏良
朱乘婧
刘济生
TENG Weiqiang;WANG Qiuyang;MA Yi;ZHANG Caiyun;ZHENG Hongliang;ZHU Chengjing;LIU Jisheng(Department of Otolaryngology Head and Neck Surgery,The First Affiliated Hospital of Naval Medical University(Second Military Medical niversity),Shanghai 200433,China;Department of Otolaryngology Head and Neck Surgery,The First Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu,China)
出处
《海军军医大学学报》
CAS
CSCD
北大核心
2024年第9期1127-1133,共7页
Academic Journal of Naval Medical University
基金
国家自然科学基金(81970868,81972537,81200734)。
关键词
甲状腺肿瘤
分子机制
分子标志物
癌基因
基因突变
基因重排
thyroid neoplasms
molecular mechanism
molecular markers
oncogene
gene mutation
gene rearrangement
