摘要
目的研究新生儿呼吸窘迫综合征(Neonatal Respiratory Distress Syndrome,NRDS)同步间歇指令通气(Synchronized Intermittent Mandatory Ventilation,SIMV)与高频振荡通气(High Frequency Oscillatory Ventilation,HFOV)的效果。方法回顾性选取2021年1月至2024年1月在漳州市医院使用过同步间歇指令通气或高频振荡通气模式之一的新生儿呼吸窘迫综合征患儿80例,依据通气方法分为HFOV组和SIMV组,每组各40例。对比两组患儿不同时段的动脉血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、氧合指数(OI)、吸氧浓度(FiO_(2))、平均气道压(MAP)等血气指标的变化,并观察两组患儿并发症的发生率。结果上机后1 h、6 h、12 h,HFOV组患儿的PaCO_(2)、FiO_(2)、OI均低于SIMV组,PaO_(2)均高于SIMV组(P<0.05);上机后1 h、6 h、12 h、24 h、48 h,HFOV组患儿的MAP均高于SIMV组(P<0.05),上机时间、住院时间均短于SIMV组,气胸、支气管肺发育不良、血压降低、肺出血、颅内出血发生率均低于SIMV组(P<0.05)。结论新生儿呼吸窘迫综合征HFOV较SIMV具有更好的临床疗效,并发症发生率更低。
Objective To investigate the efficacy of synchronous intermittent mandatory ventilation(SIMV)versus high-frequency oscillatory ventilation(HFOV)in treating neonatal respiratory distress syndrome(NRDS).Methods A retrospective study was conducted on 80 neonates with NRDS who received either SIMV or HFOV at Zhangzhou Hospital from January 2021 to January 2024.The patients were divided into two groups based on the ventilation method,with 40 cases in each group.The changes in arterial partial pressure of oxygen(PaO_(2)),partial pressure of carbon dioxide(PaCO_(2)),oxygenation index(OI),fraction of inspired oxygen(FiO_(2)),and mean airway pressure(MAP)were compared between the two groups at different time points.Additionally,the incidence rates of complications were observed and compared between the two groups.Results At 1 hour,6 hours,and 12 hours post-ventilation,the HFOV group had lower PaCO_(2),FiO_(2),and OI levels and higher PaO_(2) levels compared to those of the SIMV group(P<0.05).At 1 hour,6 hours,12 hours,24 hours,and 48 hours post-ventilation,the MAP in the HFOV group was significantly higher than that in the SIMV group(P<0.05).The HFOV group also had shorter ventilation duration and hospital stay,as well as lower incidences of pneumothorax,bronchopulmonary dysplasia,hypotension,pulmonary hemorrhage,and intracranial hemorrhage compared to those of the SIMV group(P<0.05).Conclusion HFOV demonstrates better clinical efficacy and lower complication rates compared to SIMV in the treatment of neonatal respiratory distress syndrome.
作者
谢娜
XIE Na(Department of Neonatology,Zhangzhou Hospital,Fujian Medical University,Zhangzhou 363099,China)
出处
《中华灾害救援医学》
2024年第7期790-793,共4页
Chinese Journal of Disaster Medicine
关键词
呼吸窘迫综合征
新生儿
高频通气
呼吸
respiratory distress syndrome,newborn
high-frequency ventilation
respiration
