摘要
Bacterial infections cause severe health conditions,resulting in a significant economic burden for the public health system.Although natural phytochemicals are considered promising anti-bacterial agents,they suffer from several limitations,such as poor water solubility and low bioavailability in vivo,severely restricting their wide application.Herein,we constructed a near-infrared(NIR)-responsive carrier-free berberine hydrochloride(BH,phytochemicals)/indocyanine green(ICG,photosensitizer)nanoparticles(BI NPs)for synergistic antibacterial of an infected wound.Through electrostatic interaction andπ-πstacking,the hydrophobic BH and amphiphilic ICG are initially self-assembled to generate carrier-free nanoparticles.The obtained BI NPs demonstrated NIR-responsive drug release behavior and better photothermal conversion efficiency of up to 36%.In addition,BI NPs stimulated by NIR laser exhibited remarkable antibacterial activity,which realized the synergistic antibacterial treatment and promoted infected wound healing.In summary,the current research results provided a candidate strategy for self-assembling new BI NPs to treat bacterial infections synergistically.
基金
supported by the National Key Research&Development Program of China(2019YFE0113600)
the National Natural Science Foundation of China(NSFC 81971734,32071323,32271410)
the Science and Technology Projects in Fujian Province(2022FX1,2023Y4008)
the Program for Innovative Research Team in Science,Scientific Research Funds of Huaqiao University(21BS113)is gratefully acknowledged.
