摘要
目的探究丙戊酸钠与左乙拉西坦对原发性癫痫患儿治疗效果及脑电图评定结果改善情况。方法收集长沙中心医院2022年1月至2023年6月收治的96例原发性癫痫患儿,年龄3~12岁,按照随机数字表法将其分为丙戊酸钠组和左乙拉西坦组,每组48例。分别应用丙戊酸钠和左乙拉西坦治疗,比较两组患儿治疗效果、治疗前后脑电活动情况及不良反应发生率。结果左乙拉西坦组治疗有效率高于丙戊酸钠组(χ^(2)=4.414,P=0.036)。治疗后,左乙拉西坦组每月癫痫发作次数少于丙戊酸钠组,癫痫发作持续时间短于丙戊酸钠组(P<0.001);左乙拉西坦组20 min内痫样放电次数及30 s内δ波、θ波次数均较丙戊酸钠组少,α波次数较丙戊酸钠组多(P<0.001);左乙拉西坦组韦氏儿童智力量表评分较丙戊酸钠组高(P<0.001)。左乙拉西坦组不良反应发生率较丙戊酸钠组高(χ^(2)=4.667,P=0.031),两组均未发生严重不良反应。结论在原发性癫痫患儿治疗中,与丙戊酸钠相比,应用左乙拉西坦可提升治疗效果,改善患儿癫痫症状及脑电波活动,但不良反应发生率高。
Objective To explore the therapeutic effect of sodium valproate and levetiracetam on children with primary epilepsy and the improvement of EEG assessment results.Methods A total of 96 children with primary epilepsy,aged 3-12 years old,admitted to Changsha Central Hospital from January 2022 to June 2023 were collected and divided into valproate group and levetiracetam group according to random number table method,with 48 cases in each group.Patients were treated with sodium valproate and levetiracetam respectively in the two groups.The therapeutic effect,EEG activity before and after treatment and the incidence of adverse reactions were compared between the two groups.Results The effective rate in levetiracetam group was higher than that in valproate group(χ^(2)=4.414,P=0.036).After treatment,the number of seizures per month in levetiracetam group was less than that in valproate group,and the duration of seizures was shorter than that in valproate group(P<0.001).The number of epileptic discharge within 20 min andδwave andθwave within 30 s in levetiracetam group was less than that in valproate group,and the number ofαwave was more than that in valproate group(P<0.05).The Wechsler intelligence scale score in levetiracetam group was higher than that in valproate group(P<0.001).The incidence of adverse reactions in levetiracetam group was higher than that in valproate group(χ^(2)=4.667,P=0.031).Conclusion Compared with sodium valproate,levetiracetam can improve the treatment effect,improve epilepsy symptoms and brain wave activity in children with primary epile psy,but has a higher incidence of adverse reactions.
作者
黎燕
Li Yan(Department of Pediatrics,South China University Affiliated Changsha Central Hospital,Changsha City,Hunan Province,410000,China)
出处
《现代电生理学杂志》
2024年第3期143-146,共4页
Journal of Modern Electrophysiology
关键词
癫痫
左乙拉西坦
丙戊酸
脑电描记术
儿童
Epilepsy
Levetiracetam
Valproic acid
Electroencephalography
Children
