摘要
非酒精性脂肪性肝病(Nonalcoholic fatty liver disease,NAFLD)发病率逐年升高,目前尚无特效药物。绿茶的有效成分表没食子儿茶素没食子酸酯(Epigallocatechin gallate,EGCG)在低剂量范围内已被证明对NAFLD具有良好的改善作用。综述总结了EGCG通过抗氧化应激、抗炎、抑制铁死亡、减少脂质生成、调节自噬、调节肠道菌群以及降低胆汁酸代谢等方面延缓NAFLD发生发展的部分机制,以期为改善NAFLD的深入研究提供启示。
The incidence of nonalcoholic fatty liver disease(NAFLD)is increasing year by year and there is no specific drug available.The active ingredient of green tea,epigallocatechin gallate(EGCG),has been widely proven to have a favorable ameliorative effect on NAFLD in the low dose range.Some of the mechanisms by which EGCG delays the development of NAFLD through anti-oxidative stress,anti-inflammation,inhibition of iron death,reduction of lipogenesis,up-regulation of autophagy,modulation of intestinal flora,and reduction of bile acid metabolism were summarized in this paper,so as to provide insights for in-depth research on improving NAFLD.
作者
陈佳欣
张锦佳
左会灵
焦宇航
石安华
CHEN Jiaxin;ZHANG Jinjia;ZUO Huiling;JIAO Yuhang;SHI Anhua(Yunnan University of Chinese Medicine,Kunming 650500,China;Key Laboratory of Microcosmic Syndrome Differentiation for TCM Syndromes in Universities of Yunnan Province,Kunming 650500,China)
出处
《茶叶科学》
CAS
CSCD
北大核心
2024年第4期543-553,共11页
Journal of Tea Science
基金
国家自然科学基金(82360863)、云南省科学技术厅中医联合专项-重点项目(202001AZ070001-005)。
