摘要
目的探讨乳脂球表皮生长因子8(MFG-E8)与阿尔茨海默病(AD)的关联。方法使用阿尔茨海默病神经影像计划数据库,多元线性回归用来研究MFG-E8与AD病理标志物以及脑结构的关联并进行亚组分析。使用混合效应模型研究MFG-E8与AD病理标志物和脑结构的纵向变化。中介分析用来研究MFG-E8与AD病理和脑结构之间的潜在关联。结果一共377例纳入研究,MFG-E8水平与脑脊液中β淀粉样蛋白42(Aβ_(42)),tau蛋白以及磷酸化tau蛋白(P-tau)浓度呈正相关,亚组分析结果显示,在男性、老年人以及携带APOE4基因的人群中,MFGE8水平与AD病理标志物的浓度及侧脑室体积的大小关联与总体人群一致。纵向结果表明,在随访时间内,MFGE8水平的升高与侧脑室体积扩大显著相关。此外,MFG-E8可通过影响Aβ_(42)水平改变侧脑室体积。结论MFG-E8与AD存在关联,可能通过AD病理标志物影响侧脑室体积变化。
Objective To investigate the association between milk fat globule-epidermal growth factor 8(MFGE8)and Alzheimer disease(AD).Methods The Alzheimer’s Disease Neuroimaging Initiative database was used,and a multiple linear regression analysis was used to investigate the association of MFG-E8 with the pathological markers of AD and brain structure and perform subgroup analyses.The mixed-effects model was used to investigate the longitudinal changes in MFG-E8 with AD pathological markers and brain structure,and a mediation analysis was used to investigate the potential association of MFG-E8 with AD pathology and brain structure.Results A total of 377 individuals were enrolled in the study.The level of MFG-E8 was positively correlated with the concentrations of amyloidβ-protein 42(Aβ_(42)),tau protein,and phosphorylated tau protein in cerebrospinal fluid,and subgroup analyses showed that the correlation of MFGE8 with the concentrations of AD pathological markers and lateral ventricular volume in male individuals,the elderly population,and the individuals carrying the APOE4 gene was consistent with that in the overall population.Longitudinal studies showed that during follow-up,the increase in MFG-E8 level was significantly associated with enlarged lateral ventricle volume.In addition,MFG-E8 could alter lateral ventricle volume by affecting the level of Aβ_(42).Conclusion MFG-E8 is associated with AD and may influence lateral ventricular volume through AD pathological markers.
作者
张子豪
朱阳可
王誉静
马灵志
谭兰
ZHANG Zihao;ZHU Yangke;WANG Yujing(Qingdao University Medical College,Department of Neurology,Qingdao Municipal Hospi-tal,Qingdao 266071,China)
出处
《中风与神经疾病杂志》
CAS
2024年第8期686-691,F0002,共7页
Journal of Apoplexy and Nervous Diseases
基金
国家自然科学基金(82271475,82201587)。
