摘要
灯盏乙素是从菊科植物短莛飞蓬Erigeron breviscapus(灯盏花)中提取得到的黄酮类化合物。作为其最主要的有效成分,灯盏乙素具有抗炎、抗氧化、抗纤维化、抗胆固醇血症、抗心肌梗死等药理活性。近年来,其抗肿瘤作用被逐渐发现并受到广泛关注。研究发现灯盏乙素能显著抑制非小细胞肺癌、结直肠癌、肝癌、黑色素瘤、骨髓瘤、宫颈癌、乳腺癌、卵巢癌、前列腺癌等癌症的发生发展。其抗肿瘤作用机制包括抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、阻碍肿瘤侵袭和迁移、减轻肿瘤炎症反应、增强抗肿瘤药物敏感性等多个方面,在抗肿瘤治疗领域具有巨大开发潜力。结合文献,针对灯盏乙素抗肿瘤作用机制进行综述,以期为进一步的研究和应用提供参考。
Scutellarin is a flavonoid compound extracted from Erigeron breviscapus.As a main active ingredient,scutellarin has a wide range of pharmacological properties such as anti-inflammatory,antioxidant,anti-fibrotic,anti-cholesterol,anti-myocardial infarction,etc.In recent years,its antitumor effect has been gradually discovered and widely concerned.Some researchers have found that scutellarin can significantly inhibit the occurrence and development of non-small cell lung cancer,colorectal cancer,liver cancer,melanoma,myeloma,cervical cancer,breast cancer,ovarian cancer,prostate cancer,and other cancers.The anti-tumor mechanism includes inhibiting tumor cell proliferation,promoting tumor cell apoptosis,hindering tumor invasion and migration,reducing tumor inflammatory response,and enhancing the sensitivity of antitumor drugs.It has great potential in the field of anti-tumor therapy.By combining literatures,this paper reviews the anti-tumor mechanism of scutellarin to provide references for further investigation and application.
作者
王佳恩
殷子喻
马莉
李双良
符德欢
WANG Jiaen;YIN Ziyu;MA Li;LI Shuangliang;FU Dehuan(Yunnan Institute of Materia Medica,Kunming 650111,China;Yunnan Province Company Key Laboratory of New Drug Creation of TCM and Ethnic Drug,Kunming 650111,China)
出处
《中草药》
CAS
CSCD
北大核心
2024年第13期4608-4621,共14页
Chinese Traditional and Herbal Drugs
基金
云南省重大科技专项(生物医药)(202002AA100007)。
关键词
短莛飞蓬
灯盏乙素
抗肿瘤活性
作用机制
黄酮类
Erigeron breviscapus(Vant.)Hand.-Mazz.
scutellarin
antitumor activity
mechanism of action
flavonoids
