摘要
目的:探讨外周血红细胞分布宽度(RDW)、平均血小板容积(MPV)、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)及淋巴细胞与单核细胞比值(LMR)在肺癌中的诊断价值。方法:选取113例肺癌患者(肺癌组)和113例体检健康者(对照组)。检测两组全血细胞并计算NLR、PLR、MPV。绘制受试者工作特征(ROC)曲线分析RDW、MPV、NLR、LMR和PLR对肺癌的诊断价值。结果:肺癌组患者RDW、NLR、PLR和MPV值高于对照组,LMR低于对照组(均P<0.05)。RDW、MPV、NLR、PLR和LMR在肺癌组不同病理学亚组间比较差异无统计学意义(均P>0.05)。RDW、MPV、NLR、PLR、LMR的曲线下面积(AUC)分别为0.600、0.629、0.882、0.788、0.868,而五项联合诊断肺癌的AUC(0.933)更高(均P<0.05)。结论:肺癌患者外周血RDW、NLR、PLR和MPV升高,LMR降低,五项联合对肺癌的诊断价值较高。
Objective:To investigate the diagnostic value of peripheral blood RDW,MPV,NLR,PLR and LMR in lung cancer.Methods:A total of 113 patients with lung cancer(lung cancer group)and 113 healthy subjects(control group)were selected.The whole blood cells of the two groups were detected and NLR,PLR and MPV were calculated.Receiver operating characteristic(ROC)curves were drawn to analyze the diagnostic value of RDW,MPV,NLR,LMR and PLR in lung cancer.Results:RDW,NLR,PLR and MPV in lung cancer group were higher than those in control group,and LMR was lower than that in control group(all P<0.05).There was no significant difference in RDW,MPV,NLR,PLR and LMR among different pathological subgroups of lung cancer group(all P>0.05).The area under the curve(AUC)of RDW,MPV,NLR,PLR and LMR were 0.600,0.629,0.882,0.788 and 0.868,respectively,while the AUC of the combined diagnosis of lung cancer was higher(all P<0.05).Conclusion:Peripheral blood RDW,NLR,PLR and MPV are increased in patients with lung cancer,while LMR is decreased,and the combination of the five has high diagnostic value for lung cancer.
作者
黄丹丹
陈志祥
吴文龙
许静
安钱
HUANG Dandan;CHEN Zhixiang;WU Wenlong;XU Jing;AN Qian(Department of Respiratory and Critical Care Medicine,Wuhu Hospital of Traditional Chinese Medicine,Anhui College of Traditional Chinese Medicine,Wuhu 241000,China)
出处
《陕西医学杂志》
CAS
2024年第8期1047-1050,共4页
Shaanxi Medical Journal
基金
国家自然科学基金区域创新联合基金资助项目(U20A20398)
安徽省芜湖市科技项目(2022CG36)。
