摘要
目的:探讨司美格鲁肽注射液对早期2型糖尿病肾病(T2DN)患者肾功能及促炎因子的影响。方法:选取2021年9月—2022年3月南阳市第一人民医院就诊的120例早期T2DN患者作为研究对象,按照随机数表法将分为对照组与观察组,每组各60例。对照组患者给予常规治疗,观察组患者给予司美格鲁肽注射液治疗,均连续治疗12周。比较两组患者空腹血糖(FBG)、糖化血红蛋白(HbAlc)、肾功能指标[血尿素氮(BUN)、血肌酐(Cr)、尿白蛋白肌酐比值(UACR)]及促炎因子[白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)]。结果:治疗后,两组患者FBG、HbAlc水平均较治疗前明显降低,且观察组明显低于对照组,差异有统计学意义(t=3.162、3.046,P<0.05);治疗后,两组患者Cr、UACR水平均较治疗前明显降低,且观察组明显低于对照组,差异有统计学意义(t=5.261、8.426,P<0.05);治疗后,两组患者血清IL-6、TNF-α水平均较治疗前明显降低,且观察组明显低于对照组,差异有统计学意义(t=3.357、3.814,P<0.05)。结论:司美格鲁肽注射液能有效控制早期T2DN患者的血糖水平,改善肾功能,降低促炎因子水平。
Objective:To discuss the effect of semaglutide injection on renal function and proinflammatory factors in patients with early diabetic nephropathy(DN).Methods:According to the random number table method,120 patients with early DN who were divided into control group and observation group in the hospital from September 2021 to March 2022,with 60 cases in each group.The control group was given routine treatment,while the observation group was given semaglutide injection treatment(once a week),all the patients were treated continuously for 12 weeks.The fasting blood glucose(FBG),glycosylated hemoglobin(HbAlc),renal function indicators[blood urea nitrogen(BUN),serum creatinine(Cr),urinary albumin creatinine ratio(UACR)]and proinflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]were compared between the two groups.Results:After treatment,the levels of FBG and HbAlc in 2 groups were significantly lower than before treatment,and the observation group was significantly lower than the control group,with statistically significant difference(t=3.162,3.046;P<0.05).After treatment,the levels of Cr and UACR in 2 groups were significantly lower than before treatment,and the observation group was significantly lower than the control group,with statistically significant difference(t=5.261,8.426;P<0.05).After treatment,the serum levels of IL-6 and TNF-αin 2 groups were significantly lower than before treatment,and the observation group was significantly lower than the control group,with statistically significant difference(t=3.357,3.814;P<0.05).Conclusion:The semaglutide injection can effectively control the blood glucose level of patients with early T2DN,improve renal function,and reduce the levels of proinflammatory factors.
作者
王前
王翼华
Wang Qian;Wang Yihua(Department of Endocrinology,Nanyang First People’s Hospital,Nanyang,Henan,473000,China)
出处
《黑龙江医学》
2024年第13期1570-1572,共3页
Heilongjiang Medical Journal
关键词
糖尿病肾病
2型糖尿病
美格鲁肽注射液
肾功能
促炎因子
Diabetic nephropathy
Type 2 diabetes mellitus
Semaglutide injection
Renal function
Proinflammatory factors
