摘要
目的:探讨超声收缩期峰值血流速度(PSV)、阻力指数(RI)与乳腺癌组织中Survivin、基质金属蛋白酶-11(MMP-11)、人类表皮生长因子受体2(HER2)的关系。方法:选取60例乳腺癌患者作为观察组,另选择同期60例乳腺良性病变患者作为对照组。均行手术治疗,术前经超声检测,比较两组患者术前RI值、PSV值,免疫组化法检测术后癌组织中Survivin、MMP-11、HER2的表达,分析Survivin、MMP-11、HER2表达与超声RI、PSV值的关系。结果:观察组RI、PSV值高于对照组(均P<0.05)。观察组癌组织中Survivin、MMP-11、HER2表达阳性率高于对照组(均P<0.05)。不同病灶直径、临床分期患者RI、PSV值,不同病灶直径、临床分期及是否淋巴结转移患者癌组织中Survivin、MMP-11、HER2表达比较,差异有统计学意义(均P<0.05)。癌组织中Survivin、MMP-11、HER2表达与PSV、RI值呈正相关(均P<0.05)。结论:超声检测RI、PSV值对术前判断乳腺癌有一定价值,RI、PSV值与乳腺癌癌组织Survivin、MMP-11、HER2表达均相关,Survivin、MMP-11、HER2在乳腺癌的发生、发展过程中发挥重要作用。
Objective:To investigate the relationship between peak systolic blood flow velocity(PSV),Resistance Index(RI)and Survivin,matrix metalloproteinase-11(MMP-11),human epidermal growth factor receptor 2(HER2)in breast cancer tissues.Methods:A total of 60 patients with breast cancer were selected as the observation group,and 60 patients with benign breast lesions in the same period were selected as the control group.All patients underwent surgical treatment and were detected by ultrasound before operation.Preoperative RI and PSV values were compared between the two groups,and the expressions of Survivin,MMP-11 and HER2 in postoperative cancer tissues were detected by immunohistochemistry,and the relationship between expressions of Survivin,MMP-11,HER2 and ultrasonic RI and PSV values was analyzed.Results:The RI and PSV values in observation group were higher than those in control group(all P<0.05).The expression positive rates of Survivin,MMP-11 and HER2 in observation group were higher than those in control group(all P<0.05).There were significant differences in RI,PSV,Survivin,MMP-11 and HER2 expression among patients with different lesion diameter and clinical stage,and among patients with or without lymph node metastasis(all P<0.05).The expressions of Survivin,MMP-11 and HER2 in cancer tissues were positively correlated with PSV and RI values(all P<0.05).Conclusion:Ultrasonographic detection of RI and PSV values is valuable for preoperative diagnosis of breast cancer.RI and PSV values are correlated with Survivin,MMP-11 and HER2 expression in breast cancer tissues.Survivin,MMP-11 and HER2 play an important role in the occurrence and development of breast cancer.
作者
王志泉
陈岩
高姗
刘彦丽
靳元
WANG Zhiquan;CHEN Yan;GAO Shan;LIU Yanli;JIN Yuan(The Fifth Affiliated Hospital of Qiqihar Medical College,Daqing 163000,China)
出处
《陕西医学杂志》
CAS
2024年第7期910-913,930,共5页
Shaanxi Medical Journal
基金
黑龙江省自然科学基金资助项目(9163516)。
