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高同型半胱氨酸血症对心血管病进程的加速作用 被引量：2

The Accelerating Effect of Hyperhomocysteinemia on the Progression of Cardiovascular Disease
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摘要 同型半胱氨酸(homocysteine, Hcy)作为人体甲硫氨酸的代谢产物,其体内水平与多种疾病的发病相关。高同型半胱氨酸血症(hyperhomocysteinemia, HHcy)是全身动脉粥样硬化、心血管病(cardiovascular disease, CVD)以及中风发病的独立危险因素。Hcy诱导的炎症反应、脂代谢异常、凝血功能障碍等,将严重影响血管的正常结构与功能,从而加速动脉粥样硬化的进程。服用叶酸和B族维生素,可以有效降低HHcy患者血液Hcy水平。本文将围绕HHcy加速CVD进程的机制进行综述,从而为临床预防和治疗HHcy提供新思路。 Homocysteine(Hcy),a metabolite of methionine in the human body,is associated with the pathogenesis of various diseases.Hyperhomocysteinemia(HHcy)is an independent risk factor for the onset and development of systemic atherosclerosis,cardiovascular disease(CVD),and stroke.The inflammatory reactions,lipid metabolism abnormalities,and coagulation dysfunction induced by Hcy seriously affect the normal structure and function of blood vessels,thereby accelerating the progression of atherosclerosis.Supplementation with folic acid and B vitamins can effectively reduce blood Hcy levels in patients with HHcy.This article reviews the mechanism by which HHcy accelerates the progression of CVD,providing new insights for clinical prevention and treatment of HHcy.
作者 王淑美 刘雅欣 赵一桐 任清照 林凡琪 李明光 WANG Shu-Mei;LIU Ya-Xin;ZHAO Yi-Tong;REN Qing-Zhao;LIN Fan-Qi;LI Ming-Guang(College of Laboratory Medicine,Jilin Medical University,Jilin 132013,China)
机构地区 吉林医药学院检验学院
出处 《生理科学进展》 CAS 北大核心 2024年第3期248-256,共9页 Progress in Physiological Sciences
基金 吉林省教育厅科学技术研究规划项目(JJKH20220472KJ) 吉林省卫生健康科技能力提升项目(2021JC045) 吉林省大学生创新创业训练计划项目(202213706006)资助课题。
关键词 同型半胱氨酸 高同型半胱氨酸血症 心血管病 致病机制 H型高血压 homocysteine hyperhomocysteinemia cardiovascular disease pathogenic mechanism H-type hypertension
分类号 Q591.9 [生物学—生物化学] R541.4 [医药卫生—心血管疾病]
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生理科学进展
2024年 第3期

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