摘要
阿尔茨海默病(AD)是一种神经退行性疾病,其主要特征是记忆和认知功能的进行性下降。尽管在过去几十年里对AD的研究取得了一些进展,但其确切病因仍然不清楚,目前尚无可靠的治疗方法。这引起了对新型治疗策略的迫切需求,特别是对不良反应小、疗效好的神经保护药物的需求。天然植物提取物中的是一类甾体或三萜皂苷类化合物,具有多种药理活性,被认为在AD的预防和治疗中具有巨大的潜力。研究表明,天然皂苷可能通过多种途径发挥作用,包括减少淀粉样蛋白β肽的沉积、抑制Tau蛋白的异常磷酸化、调节氧化应激、减少炎症反应及抑制细胞凋亡等。特别是,一些含有天然皂苷成分的中药制剂已经显示出在AD治疗中的潜在优势,具有重要的临床应用前景。该文综述了天然植物提取后的皂苷类化合物在AD防治方面的研究进展,并对其作用机制进行了深入探讨。通过对这些研究的综合分析,揭示了皂苷在AD治疗中的潜在机制,旨在为新型治疗药物的研发提供了重要参考,并期待未来能够通过进一步的研究和临床实验,充分挖掘其在AD治疗中的潜力,并为患者提供更有效的治疗选择。
Alzheimer's disease(AD)is a neurodegenerative disorder characterized by progressive decline in memory and cognitive function.Despite some achievements in AD research over the past few decades,its exact etiology remains elusive,with no reliable treatment currently available.This has spurred an urgent need for novel therapeutic strategies,particularly for neuroprotective agents with minimal side effects and high efficacy.Natural plant extracts contain a class of steroidal or triterpenoid saponin compounds,exhibiting various pharmacological activities,and they are believed to hold immense potential in the prevention and treatment of AD.Studies have indicated that natural saponins may exert their effects through multiple pathways,including reducing amyloid-βpeptide deposition,inhibiting abnormal phosphorylation of Tau protein,modulating oxidative stress,decreasing inflammatory responses,and suppressing cell apoptosis.Particularly,certain traditional Chinese medicine(TCM)formulations containing natural saponin components have demonstrated promising advantages in AD treatment,offering significant clinical prospects.This review summarized the research progress on saponin compounds extracted from natural plants in the prevention and treatment of AD and delved into their mechanisms of action.Through comprehensive analysis of these studies,the potential mechanisms of saponins in AD treatment were elucidated,aiming to provide valuable insights for the development of novel therapeutic drugs,and the review hopes that future research and clinical experiments will fully explore their potential in AD treatment,offering more effective therapeutic options for patients.
作者
徐亚南
柳成刚
XU Yanan;LIU Chenggang(School of Basic Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第13期240-249,共10页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家中医药管理局龙江医学流派传承工作室建设项目(LPGZS2012-14)。
关键词
阿尔茨海默病
三萜皂苷
甾体皂苷
作用机制
Alzheimer's disease
triterpenoid saponins
steroidal saponins
mechanism of action
