摘要
常春藤皂苷元是一种五环三萜类化合物,具有多种生物活性,并有着抗肿瘤、抗抑郁、抗炎和抗菌等药理作用,其通过调控细胞凋亡、自噬及细胞周期影响肿瘤的进展,并对抑郁症、阿尔茨海默病和骨关节炎等疾病有一定的改善作用。常春藤皂苷元衍生物α-常春藤皂苷元在抗肿瘤研究中也表现出了一定的潜力,其可以诱导肿瘤细胞凋亡和铁死亡,在抑制细胞增殖和转移等方面发挥抗癌作用。本文通过整合近年来常春藤皂苷元及其衍生物的研究成果,进行综述探讨。
Hederagenin is a pentyclic triterpenoid compound with a variety of biological activities and pharmacological effects such as anti-tumor,anti-depressant,anti-inflammatory and anti-bacterial.Hederagenin affects the progression of tumors by regulating apoptosis,autophagy and cell cycle,and has a certain improvement effect on depression,Alzheimer′s disease,osteoarthritis and other diseases.Theα-hederagenin,derivative of hederagenin,has also shown certain potential in anti-tumor research.It can induce apoptosis and ferroptosis of tumor cells,and play an anti-cancer role in inhibiting cell proliferation and metastasis.In this paper,the research results of hederagenin and its derivative in recent years are summarized and discussed.
作者
鲍姝畅
李松哲
蔡凌云
孙阳
Bao Shuchang;Li Songzhe;Cai Lingyun;Sun Yang(School of Basic Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中国医药》
2024年第7期1083-1086,共4页
China Medicine
基金
国家自然科学基金(81704054)
黑龙江省博士后科研启动金资助项目(LBH-Q19184)。
关键词
常春藤皂苷元
药理作用
衍生物
抗肿瘤
Hederagenin
Pharmacological effects
Derivative
Anti-tumor
