功能性消化不良动物模型的中医证型及其评价指标研究进展被引量：2

Research progress on animal models of functional dyspepsia in traditional Chinese medicine syndromes and evaluation indicators

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摘要功能性消化不良(FD)作为功能性胃肠病,中医临床通过病症结合的方式进行治疗,将其分为脾虚气滞证、肝胃不和证、脾胃湿热证、脾胃虚寒证、寒热错杂证、肝郁脾虚证、肝郁气滞证等证型。FD动物模型的构建依据证型特定的发病机制来模拟人体症状,检测指标常采用行为学、胃肠动力学及相关蛋白水平等评估模型与FD患者的相似度。符合病症的动物模型是开展药效研究和药效评价的前提和基础,对FD中医证型的造模方法及检测指标进行整理和分析,旨在完善和优化动物模型,为后续的药物研究提供支持。 Functional dyspepsia(FD),as a functional gastrointestinal disease,is treated in traditional Chinese medicine through a combination of symptoms and symptoms.FD is divided into spleen deficiency and qi stagnation syndrome,liver stomach disharmony syndrome,spleen stomach damp heat syndrome,spleen stomach deficiency and cold syndrome,mixed cold and heat syndrome,liver depression and spleen deficiency syndrome,and liver depression and qi stagnation syndrome.The construction of FD animal models is based on the specific pathogenesis of syndrome types to simulate human FD symptoms,and detection indicators often use behavioral,gastrointestinal dynamics,and related protein levels to evaluate the similarity between the model and FD patients.Animal models that meet the symptoms are the prerequisite and foundation for conducting pharmacological research and evaluation.The modeling methods and detection indicators of traditional Chinese medicine syndrome types in FD are currently organized and analyzed,aiming to improve and optimize the FD animal model and provide support for subsequent drug research.

作者马玉朋袁亚茹邸志权姜溪胡金芳 MA Yupeng;YUAN Yaru;DI Zhiquan;JANG Xi;HU Jinfang(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Tiancheng Drug Assessment Co.Ltd.,Tianjin 300462,China;Anhui Medical University,Hefei 230032 China;National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine,Tianjin 300462,China;Tianjin Key Laboratory of Pharmacokinetics and Pharmacodynamics,Tianjin 300462,China;Tianjin Engineering Research Center of Drug Preclinical Assessment Technology,Tianjin 300462,China)

机构地区天津中医药大学天津天诚新药评价有限公司安徽医科大学药物成药性评价与系统转化全国重点实验室天津市药代动力学和药效动力学重点实验室天津市新药非临床评价技术工程中心

出处《药物评价研究》 CAS 北大核心 2024年第4期889-896,共8页 Drug Evaluation Research

基金国家科技重大新药创制资助项目(2015ZX09501004) 天津市科技计划资助项目(16PTGCCX00090,17ZXXYSY00020)。

关键词功能性消化不良动物模型中医证型病证结合评价指标 functional dyspepsia animal models traditional Chinese medicine syndrome types combination of disease and syndrome evaluating indicator

分类号 R965.1 [医药卫生—药理学]