摘要
年龄相关性黄斑变性(AMD)是导致老年患者视力下降甚至失明的常见原因,随着人口老龄化和寿命延长,AMD已成为日益重要的公共卫生问题,目前其发病机制尚不完全明确。代谢组学作为一门研究代谢产物的变化规律并揭示生命活动本质的科学,可以通过分析AMD患者独特的代谢产物和综合代谢状况,成为筛查和评估AMD进展的潜在生物标志物。本文通过梳理国内外相关文献,针对AMD相关的代谢组学研究,以血浆、血清、房水和玻璃体以及尿液等体液研究为主体进行综述,发现多数差异代谢物为脂质、氨基酸、核苷酸,主要涉及的代谢通路为氨基酸代谢、糖代谢、肉碱代谢等。代谢组学在AMD中的应用正在快速发展,有望为AMD的进展提供个性化的预防策略和靶向治疗方法。
Age-related macular degeneration(AMD)is a common cause of visual impairment and even blindness in elderly patients.With the aging population and increased life expectancy,AMD has become an increasingly important public health issue.However,the pathogenesis of AMD is not fully understood.Metabolomics,as a scientific discipline that studies the changes in metabolites and reveals the essence of life activities,can be used to analyze the unique metabolic products and overall metabolic status of AMD patients,thus serving as potential biomarkers for screening and evaluating AMD progression.This paper,through reviewing relevant domestic and international literature,provides a comprehensive review of metabolomics studies related to AMD,focusing on fluid studies such as plasma,serum,aqueous humor,vitreous humor,and urine.The majority of differential metabolites identified are lipids,amino acids,and nucleotides,primarily involving metabolic pathways such as amino acid metabolism,sugar metabolism,and carnitine metabolism.The application of metabolomics in AMD is rapidly advancing and holds promise for providing personalized prevention strategies and targeted therapeutic approaches for AMD progression.
作者
许佑
梁凤鸣
王继芳
XU You;LIANG Fengming;WANG Jifang(First Teaching Hospital of Tianjin University of Traditional Chi-nese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibus-tion,Tianjin 300193,China)
出处
《中国中医眼科杂志》
2024年第6期576-580,共5页
China Journal of Chinese Ophthalmology
基金
国家自然科学基金项目(82174442)。
