摘要
目的观察热咳清合剂联合西医基础治疗对2型糖尿病合并社区获得性肺炎(痰热壅肺型)患者的临床疗效。方法选取2023年1月1日至2023年8月1日杭州市中医院武林院区及丁桥院区呼吸科收治的T2DM合并CAP(痰热壅肺型)患者108例,随机分为治疗组(n=54)和对照组(n=54)。对照组给予西医基础治疗方案,治疗组给予热咳清合剂并联合西医基础治疗。比较两组中医证候积分、临床疗效、PSI评分、胸部CT平扫结果、实验室指标、血糖,记录不良事件。结果治疗前两组中医症候积分比较,差异无统计学意义(P>0.05);治疗后,治疗组中医证候积分低于对照组,差异有统计学意义(P<0.05);临床疗效治疗组总有效率高于对照组(P<0.05);治疗前两组PSI评分比较,差异无统计学意义(P>0.05);治疗后PSI评分治疗组低于对照组(P<0.05);治疗前两组实验室指标(WBC、CRP、PCT水平)比较,差异无统计学意义(P>0.05),治疗后治疗组实验室指标低于对照组(P<0.05);治疗前两组影像学(CT)差异无统计学意义(P>0.05),治疗后热咳清治疗组疗效优于对照组(P<0.05);治疗前两组FPG、2 h PG比较,差异无统计学意义(P>0.05),治疗后治疗组FPG低于对照组,差异有统计学意义(P<0.05),治疗后两组2 h PG比较,差异无统计学意义(P>0.05);两组患者均未出现不良反应。结论热咳清合剂治疗痰热壅肺型T2DM合并CAP安全有效,值得临床推广。
Objective To investigate the clinical efficacy and safety of Rekeqing mixture in the treatment of type 2 diabetes mellitus(T2DM)complicated with community-acquired pneumonia(CAP)(type of phlegm-heat obstructing the lung).Methods A total of 108 patients with T2DM complicated with CAP were selected.All of them met the inclusion criteria and were randomly divided into the treatment group and the control group.The control group was treated with anti-infection and blood sugar control.The treatment group was treated with Rekeqing mixture decoction based on the treatment of the control group.Both groups were observed for 7 days.The scores of TCM symptoms,pneumonia severity index(PSI)symptoms,clinical effect(chest CT imaging before and after treatment),inflammatory indexes white blood cell(WBC),C-reactive protein(CRP),procalcitonin(PCT),blood glucose,safety indexes of the two groups were compared.Results After treatment,the TCM symptoms and the PSI symptoms of the two groups were relieved,the scores were reduced,and the effective rates of the treatment group were 92.6%,the clinical effect of the treatment group was higher than that of the control group,inflammatory indicators(WBC,CRP,PCT)and blood glucose levels were lower than before.And in the treatment group were lower than those in the control group(P<0.05).Both of the two groups of patients had no objective opposite reaction.Conclusion Rekeqing mixture is effective and safe in the treatment of T2DM complicated with CAP(type of phlegm-heat obstructing the lung),which is worthy of clinical popularization.
出处
《浙江临床医学》
2024年第5期673-676,共4页
Zhejiang Clinical Medical Journal
基金
浙江省中医药科技计划项目(2023ZL529)。
关键词
热咳清合剂
2型糖尿病
社区获得性肺炎
Rekeqing mixture
Type 2 diabetes
Community-acquired pneumonia
