摘要
一直以来,细胞器被认为具有各自特异的组成和结构,独立发挥作用。现在越来越多研究表明,相邻的不同细胞器之间可以通过蛋白-蛋白或蛋白-脂质形成膜接触点,从而发生相互作用。线粒体相关内质网膜(mitochondria-associated endoplasmic reticulum membranes,MAMs)是线粒体与内质网之间相互接触的膜结构,多种蛋白富集在MAMs上,对内质网和线粒体之间的物质交流及二者的功能,起严格的调控作用。在心肌缺血/再灌注损伤(myocardial ischemia-reperfusion injury,MIRI)中,MAMs参与线粒体分裂、线粒体自噬、氧化应激、钙失衡等一系列关键的病理进程,对病情的发展、转归起着极为重要的作用,是一个很有希望的治疗靶点。该文着重于MAMs的结构、功能和其对MIRI进程调控方面的研究进展,进行一个详细的综述。
Traditionally,organelles are regarded as isolated units having specific ingredients and structures and functioning separately.Accumulating studies have showed that neighboring different organelles can form membrane contacts through interactions of protein-protein or protein-lipid.Mitochondria-associated endoplasmic reticulum membranes,i.e.MAMs,contact these two organelles,and enrich a variety of proteins,which strictly regulate the material exchange between the endoplasmic reticulum and the mitochondria and the functions of them.In myocardial ischemia-reperfusion injury(MIRI),MAMs play an extremely important role,which controls a series of key pathological processes,such as mitochondrial division,mitochondrial autophagy,oxidative stress,and calcium overload,etc.,thus being a promising and important new therapeutic target.This paper detailedly reviews the progress in the research on MAMs′structure and function and its role in MIRI.
作者
胡爽
温静
范晓迪
李澎
HU Shuang;WEN Jing;FAN Xiao-di;LI Peng(Institute of Basic Medical Sciences,Xiyuan Hospital of China Academy of Chinese Medical Sciences;Beijing Key Laboratory of Pharmacology of Chinese Materia Medica,Beijing 100091,China;Graduate School of China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2024年第6期1001-1006,共6页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81973594)。
关键词
线粒体相关内质网膜
心肌缺血/再灌注损伤
细胞器相互作用
内质网-线粒体微域
钙信号
内质网-线粒体接触位点
mitochondria-associated endoplasmic reticulum membranes
myocardial ischemia reperfusion injury
organelle interaction
ER-mitochondria microdomains
calcium signaling
endoplasmic reticulum-mitochondria contact sites
