摘要
Kelech样环氧氯丙烷相关蛋白1-核因子E2相关因子2-抗氧化反应元件(Keap1-Nrf2-ARE)是调控动物体内多种抗氧化酶和Ⅱ相解毒酶表达的信号通路,在氧化应激反应中发挥着重要作用。研究发现,益生菌和植物提取物具有良好的抗氧化活性,作为激活剂能够激活动物体内Keap1-Nrf2-ARE信号通路,从而增强机体的抗氧化能力,缓解机体的氧化应激反应,并提高畜禽生长性能。本文首先阐述了Keap1-Nrf2-ARE信号通路各部分的基本结构和功能,然后分析了Keap1-Nrf2-ARE信号通路在机体氧化应激反应中的调控机制,最后对能够激活Keap1-Nrf2-ARE信号通路的激活剂进行了分类总结并概述了其在畜禽生产中应用的研究进展,旨在为畜牧领域新型饲料添加剂的研发以及缓解机体氧化应激的深入研究提供参考。
Kelech⁃like epichlorohydrin⁃associated protein 1⁃nuclear factor E2⁃related factor 2⁃antioxidant re⁃sponse element(Keap1⁃Nrf2⁃ARE)is a signaling pathway that regulates the expression of various antioxidant enzymes andⅡphase detoxification enzymes in animals,and plays an important role in oxidative stress re⁃sponse.Studies have found that a variety of probiotics and plant extracts with outstanding antioxidant activity can be used to activate the Keap1⁃Nrf2⁃ARE signaling pathway in animals,consequently enhancing the antioxi⁃dant capacity of the body,alleviating the oxidative stress response of the body,and improving the growth per⁃formance of livestock and poultry.This review described the basic molecular structure of each part of Keap1⁃Nrf2⁃ARE signaling pathway,and the regulatory mechanism of Keap1⁃Nrf2⁃ARE signaling pathway in oxida⁃tive stress response,and also summarized the activators that can activate Keap1⁃Nrf2⁃ARE signaling pathway,and the research progress of Keap1⁃Nrf2⁃ARE activators applied in livestock and poultry production.Based on our collected findings,we aimed to provide a reference for the development of new feed additives in the field of animal husbandry and further study on alleviating oxidative stress in animals.
作者
张朝生
陈志敏
王少龙
刘国华
ZHANG Chaosheng;CHEN Zhimin;WANG Shaolong;LIU Guohua(Key Laboratory for Feed Biotechnology of the Ministry of Agriculture and Rural Affairs,Institute of Feed Research of Chinese Academy of Agriculture Sciences,Beijing 100081,China)
出处
《动物营养学报》
CAS
CSCD
北大核心
2024年第5期2813-2829,共17页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
中国农业科学院创新工程(CAAS-ASTIP-2023-IFR-10)。
