摘要
目的:观察加味香砂六君子汤对进展期结直肠癌化疗患者炎症反应的影响。方法:选取进展期结直肠癌患者114例,采用简单随机法分为对照组57例和观察组57例。对照组按照NCCN指南给予对应的化疗方案治疗,观察组在化疗方案基础上给予加味香砂六君子汤治疗,均治疗3个周期。比较两组治疗前后Piper疲乏量表(RPFS)评分、卡氏(KPS)评分、中医证候评分和炎性因子水平差异,统计两组疗效和安全性。结果:治疗前两组RPFS评分、KPS评分、中医证候评分、炎性因子水平均无统计学差异(P>0.05)。治疗后,两组RPFS评分、中医证候评分下降,KPS评分升高,观察组RPFS评分、中医证候评分较对照组下降更明显,KPS评分较对照组升高更明显(P<0.05)。治疗后,观察组肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、白细胞介素-10(IL-10)下降,白细胞介素-4(IL-4)升高(P<0.05)。对照组治疗前后炎性因子水平差异无统计学意义(P>0.05)。观察组总有效率高于对照组(P<0.05)。观察组不良反应总发生率明显低于对照组(P<0.05)。结论:加味香砂六君子汤可调节进展期结直肠癌化疗患者炎性因子水平,提高疗效。
Objective:To observe the effects of flavored Xiangsha Liujunzi decoction on inflammation in chemotherapy patients with advanced colorectal cancer.Method:114 patients with advanced colorectal cancer were selected and divided into 57 cases in the control group and 57 cases in the observation group by simple randomization method.The control group was treated with corresponding chemotherapy regimen according to NCCN guidelines,and the observation group was treated with flavored Xiangsha Liujunzi decoction on the basis of chemotherapy regimen.The differences in Piper Fatigue Scale(RPFS)score,Kasper(KPS)score,and Chinese medicine evidence score were compared between the two groups,and inflammatory factors were detected in the two groups,and the efficacy and safety of the two groups were compared.Results:Before treatment,the difference of RPFS score,KPS score and Chinese medicine evidence score in two groups was not statistically significant(P>0.05).After treatment,the RPFS scores and Chinese medicine evidence scores were decreased,KPS scores were increased in the two groups,while the changes in the observation group were more significantly than in the control group(P<0.05).The difference of inflammatory factors in the two groups before treatment was not statistically significant(P>0.05).After treatment,tumour necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-10(IL-10)were decreased and interleukin-4(IL-4)was increased in the observation group,with statistically significant differences(P<0.05).The difference in the level of inflammatory factors before and after treatment in the control group was not statistically significant(P>0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Flavored Xiangsha Liujunzi decoction can regulate the level of inflammatory factors and improve the therapeutic efficacy in patients undergoing chemotherapy advanced colorectal cancer.
作者
郑广茂
胡少龙
陈梅玲
郭亚敏
冯艳嫔
李建军
高秀芳
ZHENG Guang-mao;HU Shao-long;CHEN Mei-ling;GUO Ya-min;FENG Yan-bing;LI Jian-jun;GAO Xiu-fang(Second Department of Gastroenterology,Zhangjiakou First Hospital,Zhangjiakou 075000,China;Department of Emergency,Zhangjiakou First Hospital,Zhangjiakou 075000,China;Department of Emergency,Zhangjiakou the second Hospital,Zhangjiakou 075000,China)
出处
《微循环学杂志》
2024年第2期31-35,共5页
Chinese Journal of Microcirculation
基金
张家口市重点研发计划项目(2221052D)。
关键词
加味香砂六君子汤
进展期结直肠癌
免疫功能
炎症因子
Flavored Xiangsha Liujunzi decoction
Advanced colorectal cancer
Inflammatory factors
