摘要
目的:系统评价肠内营养联合四君子汤对消化道肿瘤术后的临床疗效及其安全性。方法:通过计算机检索相关外文电子数据库:Cochrane图书馆、PubMed数据库和EMbase数据库,以及国内中文数据库:中国生物医学文献数据库、中国知网、重庆维普科技数据库和万方数据等,并手工检索无电子版的杂志增刊和会议论文来收集文献。筛选并纳入肠内营养联合四君子汤用于消化道肿瘤术后的临床随机对照试验,文献语种限定为中文或者英文,所有检索时间范围为各数据库建库至2022年10月1日。由两名研究人员各自独立对文献资料的各项数据进行提取,并完成对文献资料的方法学质量评价和结果分析,采用RevMan5.2.3软件进行Meta分析。结果:本次研究共纳入13个临床随机对照试验研究,研究质量均不高。Meta分析结果显示肠内营养联合四君子汤在改善消化道肿瘤术后患者的细胞免疫指标、体液免疫指标、营养指标均高于单独使用肠内营养治疗(P <0.05),而不良反应发生率的差异无统计学意义(P> 0.05)。结论:由于纳入文献篇目较少,文献质量不统一,且原始文献均为中文文献,当前的证据还不能确认该治疗方式在临床实践中是否完全有效,但是从目前的研究来看,其疗效优势值得进一步探究,尤其需要进行高质量的多中心大样本随机双盲对照试验来验证其疗效。
Objective:To systematically evaluate the clinical efficacy and safety of enteral nutrition plus the Sijunzi decoction(四君子汤)on postoperative gastrointestinal tumor.Methods:Foreign electronic databases,including Cochrane Library,PubMed,and EMbase databases,as well as Chinese databases such as SinoMed,CNKI,VIP,and Wangfang Data were searched by computer to retrieve relevant literature.Journal supplements and conference papers without electronic versions were retrieved manually.Studies of clinical randomized controlled trials about enteral nutrition plus the Sijunzi decoction for postoperative gastrointestinal tumor were screened out and included finally.The language of literature was limited to Chinese or English,and the search time range was from the establishment of each database to October 1,2022.Two researchers independently extracted the data of the literature,and assessed the methodological quality of the literature and analyzed the results.A Meta-analysis was conducted by RevMan 5.2.3 software.Results:A total of 13 RCT studies were included in this study,and the quality of these studies was not high.The Meta-analysis results showed that the cellular immune indicators,humoral immune indicators,and nutritional indicators of enteral nutrition plus the Sijunzi decoction were higher than those of enteral nutrition alone after gastrointestinal tumor surgery(P<0.05),but the incidence of adverse reactions was not statistically significant(P>0.05).Conclusion:Due to the relatively small number of included papers,inconsistent literature quality,and Chinese literature as the original literature,the current evidence cannot confirm whether this treatment method is fully effective in clinical practice.However,from the current studies,its therapeutic advantages are worth further exploration.It is particularly necessary to conduct high-quality multi-center large sample randomized double-blind controlled trials to verify its efficacy.
出处
《中医临床研究》
2024年第10期38-44,共7页
Clinical Journal Of Chinese Medicine
基金
内蒙古自治区卫生健康科技计划项目(202202253)。
关键词
四君子汤
消化道肿瘤
术后
系统评价
META分析
The Sijunzi decoction
Gastrointestinal tumor
Postoperative
Systematic assessment
Meta-analysis
