摘要
NADPH氧化酶(NADPH Oxidase,NOXs)是产生超氧化物的酶,在机体防御、生物合成途径以及细胞信号传导中发挥作用。NOXs作为活性氧(ROS)的主要来源,已成为抗氧化应激、炎症、纤维化和肿瘤的热门靶点。文献提示,NOXs及其相关的氧化还原反应与破骨细胞和成骨细胞密切相关,它驱动膜相关活性氧(reactive oxygen species,ROS)及启动铁死亡,影响骨形成和骨吸收。本文拟综述NOXs对ROS和铁死亡在骨稳态中的作用为NOXs治疗骨代谢相关疾病提供文献参考。
NADPH Oxidase(NOXs)is an enzyme that produces superoxide and plays an important role in organism defense,biosynthesis pathway and cell signal transduction.NOXs,as a major source of reactive oxygen species(ROS),has become a popular target for anti-oxidative stress,inflammation,fibrosis,and tumors.Literature suggests that NOXs and their related REDOX reactions are closely related to osteoclasts and osteoblasts,driving membrane-associated reactive oxygen species(ROS)and initiating iron death,affecting bone formation and bone resorption.This paper aims to review the effects of NOXs on ROS and iron death in bone homeostasis and provide references for the treatment of bone metabolism related diseases with NOXs.
作者
吉天英
吴建民
颜春鲁
马飞宏
王建国
常睿
罗春艳
JI Tianying;WU Jianmin;YAN Chunlu;MA Feihong;WANG Jianguo;CHANG Rui;LUO Chunyan(Clinical College of Traditional Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Orthopedic Rehabilitation,Affiliated Hospital of Gansu Unversity of Traditional Chinese Medicine,Lanzhou 730020,China;Gansu University of Chinese Medicine,College of Integrative Medicine,Lanzhou 730000,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2024年第4期595-599,共5页
Chinese Journal of Osteoporosis
基金
甘肃省中医药管理局科研课题(GZKP-2021-34)
甘肃省教育科技创新项目(2022A-072)。
