摘要
瘢痕疙瘩是皮肤损伤后由于结缔组织过度增生导致的良性纤维增生性皮肤病。其特点是体积增大超出原始损伤范围,并伴有瘙痒和刺痛。目前瘢痕疙瘩的发病机制仍未被彻底揭示,表观遗传、炎症反应、机械力作用等诸多因素对其均有影响。其中,表观遗传修饰在瘢痕疙瘩发病机制中发挥关键作用,可通过影响纤维细胞行为和基因表达来调控瘢痕疙瘩的形成与发展。本文将对瘢痕疙瘩的表观遗传修饰进行综述,为进一步研究其发病机制和创新治疗提供更多思路。
Keloid is a benign fibroproliferative skin disease that occurs after skin injury due to excessive connective tissue growth.It is characterized by an increase in volume beyond the original injury site,and is often accompanied by itching and pain.The exact mechanisms underlying the development of Keloids are still not fully understood,but epigenetic modifications,inflammatory responses,and mechanical forces have all been implicated.Among these factors,epigenetic modifications play a key role in the pathogenesis of Keloids by influencing fibroblast behavior and gene expression.This review aims to summarize the role of epigenetic modifications in Keloids,providing further insights into the understanding of its pathogenesis and potential innovative therapies.
作者
孔德祺
金文玉
金哲虎
KONG De-qi;JIN Wen-yu;JIN Zhe-hu(Department of Dermatology,Yanbian University Hospital,Jilin Province,133000,China)
出处
《中国医疗美容》
2024年第3期119-122,共4页
China Medical Cosmetology
