摘要
目的分析濮阳地区成人急性髓系白血病(AML)临床病例,探讨发病情况、预后分层和发病趋势,了解该地区成人AML流行病学特征。方法对2014年12月至2022年7月在濮阳市人民医院和油田总医院收治的105例初发AML患者进行回顾性分析,分析形态学分型、性别、年龄、基因突变、染色体异常、生存时间、预后转归和发病趋势等。结果濮阳地区AML患者亚型以M2、M4和M5为主,共90例(85.71%);男性多于女性,发病年龄多在>30~60岁;城镇患者生存期超过1 a的生存率高于农村患者,差异有统计学意义(P<0.05);基因突变检测中,CEBPA基因突变率最高(21.57%);染色体检测中,染色体数目和(或)结构异常率最高(82.47%),进行危险分层的患者,预后中等的人数最高(48.57%)。结论濮阳地区成人AML发病趋势呈现上升趋势,农村地区发病率较高且1 a生存率低,农村应该成为濮阳地区成人AML重点防控地区。
Objective To analyze the clinical cases of adult acute myeloid leukemia in Puyang area,and to investigate the incidence,prognosis stratification and incidence trend,and to understand the epidemiological characteristics of adult acute myeloid leukemia in Puyang area.Methods A retrospective analysis was performed on 105 patients with primary acute myeloid leukemia admitted to Puyang People’s Hospital and Oilfield General Hospital from December 2014 to July 2022.The morphological characteristics,sex,age,gene mutation,chromosome abnormality,survival time,prognosis and morbidity were analyzed.Results The subtypes of acute myeloid leukemia in Puyang area were mainly M2,M4 and M5,accounting for 90 cases(85.71%).Men were more than women,and the age of onset was>30-60 years old.The survival rate of urban patients with survival period over 1 year was higher than that of rural patients,and the difference was statistically significant(P<0.05).The mutation rate of CEBPA gene was the highest(21.57%).In chromosome detection,the abnormal rate of chromosome number and/or structure was the highest(82.47%),and the number of patients with moderate prognosis was the highest(48.57%)after risk stratification.Conclusion The incidence of adult acute myeloid leukemia was on the rise in Puyang area,and the incidence was higher in rural areas and 1 year survival rate was lower.Rural areas should be the key areas for prevention and control of adult acute myeloid leukemia in Puyang area.
作者
王志龙
苗朝旭
郭学军
WANG Zhilong;MIAO Zhaoxu;GUO Xuejun(Henan Medical Exchange and Project Promotion Center,Zhengzhou 450003,China;Henan Provincial Doctors Association,Zhengzhou 450003,China;Xinxiang Medical College,Xinxiang 453003,China;Puyang Oilfield General Hospital Affiliated to Xinxiang Medical College,Puyang 457001,China)
出处
《河南医学研究》
CAS
2024年第7期1160-1163,共4页
Henan Medical Research
