摘要
目的分析甲氧氯普胺联合异丙嗪在妊娠剧吐患者中的治疗效果。方法方便选取2020年5月-2022年4月六盘水市人民医院收治的妊娠剧吐患者86例为研究对象,按随机数表法分为两组,各43例。对照组予以甲氧氯普胺,观察组加用异丙嗪,连续治疗1周。对比两组临床疗效、症状改善情况、呕吐症状严重程度、生活质量、不良反应。结果观察组治疗总有效率为93.02%,高于对照组的76.74%,差异有统计学意义(χ^(2)=4.441,P<0.05),观察组的呕吐消失时间、尿酮转阴时间短于对照组,差异有统计学意义(P均<0.05);治疗前,两组孕期恶心呕吐量化表(Pregnancy-unique Quantification of Emesis and Nausea,PUQE)评分与妊娠恶心呕吐生活质量量表(Nausea and Vomiting of Pregnancy Quality of Life Questionnaire,NVPQOL)评分相比,差异无统计学意义(P均>0.05)。治疗后,观察组PUQE评分、NVPQOL评分低于对照组,差异有统计学意义(P均<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论甲氧氯普胺+异丙嗪治疗妊娠剧吐患者效果显著,可减轻其呕吐症状,促进尿酮转阴,提升生活质量,且无严重不良反应。
Objective To analyze the therapeutic effect of metoclopramide combined with promethazine in hyperemesis gravidarum.Methods A total of 86 patients with hyperemesis gravidarum admitted to Liupanshui People's Hospital from May 2020 to April 2022 were conveniently selected as the research objects and divided into two groups accord-ing to random number table method,with 43 cases in each group.The control group was treated with metoclopramide,and the observation group was treated with promethazine for 1 week.The clinical efficacy,symptom improvement,vomiting symptom severity,quality of life and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.02%,which was higher than that of the control group 76.74%,and the differences were statistically significant(χ^(2)=4.441,P<0.05).The time for vomiting to disappear and urine ketone to turn negative in the observation group were shorter than those of the control group,and the differences were statisti-cally significant(all P<0.05).Before treatment,there was no statistically significant difference of Pregnancy-unique Quantification of Nausea and Vomiting(PUQE)scores and Nausea and Vomiting Pregnancy Quality of Life Question-aire(NVPQOL)scores of each dimension between the two groups(all P>0.05).After treatment,PUQE scores,NVPQOL scores in the observation group were lower than those in the control group,and the differences were statisti-cally significant(all P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion Metoclopramide+promethazine is effective in the treatment of hyperemesis gravidarum patients,which can reduce their vomiting symptoms,promote urine ketone to negative,improve quality of life,and no serious adverse reactions.
作者
李佩
王树碧
LI Pei;WANG Shubi(Department of Obstetrics and Gynecology,Liupanshui People's Hospital,Liupanshui,Guizhou Province,553000 China)
出处
《中外医疗》
2024年第4期79-82,共4页
China & Foreign Medical Treatment
关键词
妊娠剧吐
甲氧氯普胺
异丙嗪
生活质量
尿酮
不良反应
Hyperemesis gravidarum
Metoclopramide
Promethazine
Quality of life
Urine ketone
Adverse reaction
