摘要
玉米赤霉烯酮(ZEA)是饲料中常见的霉菌毒素之一,主要影响猪的生殖系统、胃肠功能、免疫系统和细胞活力等。当猪摄入被ZEA污染的饲料后,易造成母猪流产、公猪精子活力异常、肠道炎症、降低机体免疫功能以及多种器官(肝脏、肾脏等)炎症反应,并造成细胞异常增殖、细胞氧化损伤等,引起细胞毒性,给养殖业造成严重损失。文章介绍了ZEA的理化性质、在谷物饲料中的限量标准及在猪体内的主要代谢过程,从生殖毒性、肠道毒性、免疫毒性和细胞毒性方面重点阐述了ZEA对猪的临床危害及可能的致病机理,提出了减轻ZEA毒性的主要方法以及防控措施,为推动养猪业的健康发展、确保饲料和肉制品的安全性提供参考。
Zearalenone(ZEA) is one of the common mycotoxins in feed,which mainly affects the reproductive system,gastrointestinal function,immune system,and cell viability of pigs.When pigs ingest ZEA-contaminated feed,it is easy to cause abortion in sows,abnormal sperm motility in boars,intestinal dysfunction and intestinal inflammation,reduce immune function and inflammatory reactions in liver,kidneys,and other organs,and cause abnormal cell proliferation,oxidative damage and other cytotoxicity,resulting in serious losses to pig breeding industry.The paper introduces the physicochemical properties of ZEA,the limit standard in cereal feed,and the main metabolic process in pigs.The clinical harm and possible pathogenic mechanism of ZEA to pigs are emphatically expounded by the aspects of reproductive toxicity,intestinal toxicity,immunotoxicity and cytotoxicity.The main methods to reduce the toxicity of ZEA and the prevention and control measures are put forward,which provide references for promoting the healthy development of pig industry and ensuring the safety of feed and meat products.
作者
徐文静
魏文娟
陈晓光
张自强
刘玉梅
吕琼霞
XU Wen-jing;WEI Wen-juan;CHEN Xiao-guang;ZHANG Zi-qiang;LIU Yu-mei;Lü Qiong-xia
出处
《饲料研究》
CAS
北大核心
2024年第5期166-171,共6页
Feed Research
基金
河南省重点研发与推广专项(项目编号:202102110093)。
关键词
玉米赤霉烯酮
猪
毒副作用
防控措施
zearalenone
pig
toxic and side effects
prevention and control measure
