摘要
目的探讨体力活动和成年人缺血性脑卒中发病的关联。方法使用中国慢性病前瞻性研究浙江省桐乡市数据,剔除基线时自报患有恶性肿瘤、心脏病、脑卒中和糖尿病患者后,纳入分析30~79岁53916名研究对象。体力活动分组采用五分位数。采用Cox比例风险回归模型计算缺血性脑卒中发病风险比(HR)值。结果调查对象体力活动水平为(30.63±15.25)代谢当量(MET)-h/d,男性体力活动水平[(31.04±15.48)MET-h/d]高于女性[(30.33±15.07)MET-h/d](P<0.001)。调查对象累计随访595526人年(平均随访11.4年)。随访期间,1138名男性和1082名女性被新诊断为缺血性脑卒中。在调整了社会人口学因素、行为生活方式、BMI、腰围和SBP等多种危险因素后,缺血性脑卒中发病风险随体力活动的增加而降低,趋势检验结果均有统计学意义(P<0.001)。与体力活动最低组(<16.17 MET-h/d)人群相比,中低组(16.17~24.94 MET-h/d)、中等组(24.95~35.63 MET-h/d)、中高组(35.64~43.86 MET-h/d)和最高组(≥43.87 MET-h/d)人群缺血性脑卒中发病HR值分别为0.93(95%CI:0.83~1.04)、0.87(95%CI:0.76~0.98)、0.82(95%CI:0.71~0.95)和0.76(95%CI:0.64~0.89)。结论增加体力活动可以降低缺血性脑卒中的发病风险。
Objective To explore the prospective associations between physical activity and incident ischemic stroke in adults.Methods Data of China Kadoorie Biobank study in Tongxiang of Zhejiang were used.After excluding participants with cancers,strokes,heart diseases and diabetes at baseline study,a total of 53916 participants aged 30-79 years were included in the final analysis.The participants were divided into 5 groups according to the quintiles of their physical activity level.Cox proportional hazard regression models was used to calculate the hazard ratios(HR)for the analysis on the association between baseline physical activity level and risk for ischemic stroke.Results The total physical activity level in the participants was(30.63±15.25)metabolic equivalent(MET)-h/d,and it was higher in men[(31.04±15.48)MET-h/d]than that in women[(30.33±15.07)MET-h/d](P<0.001).In 595526 person-years of the follow-up(average 11.4 years),a total of 1138 men and 1082 women were newly diagnosed with ischemic stroke.Compared to participants with the lowest physical activity level(<16.17 MET-h/d),after adjusting for socio-demographic factors,lifestyle,BMI,waist circumference,and SBP,the HRs for the risk for ischemic stroke in those with moderate low physical activity level(16.17-24.94 MET-h/d),moderate physical activity level(24.95-35.63 MET-h/d),moderate high physical activity level(35.64-43.86 MET-h/d)and the highest physical activity level(≥43.87 MET-h/d)were 0.93(95%CI:0.83-1.04),0.87(95%CI:0.76-0.98),0.82(95%CI:0.71-0.95)and 0.76(95%CI:0.64-0.89),respectively.Conclusion Improving physical activity level has an effect on reducing the risk for ischemic stroke.
作者
王浩
谢开婿
陈玲琍
曹元
沈钲杰
吕筠
余灿清
孙点剑一
裴培
钟节鸣
俞敏
Wang Hao;Xie Kaixu;Chen Lingli;Cao Yuan;Shen Zhengjie;Lyu Jun;Yu Canqing;Sun Dianjianyi;Pei Pei;Zhong Jieming;Yu Min(Department of Chronic and Non-communicable Disease Control and Prevention,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China;Department of Chronic and Non-communicable Disease Control and Prevention,Tongxiang County Center for Disease Control and Prevention,Tongxiang 314599,China;Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China;Peking University Center for Public Health and Epidemic Preparedness&Response,Beijing 100191,China;Key Laboratory of Epidemiology of Major Diseases(Peking University),Ministry of Education,Beijing 100191,China)
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2024年第3期325-330,共6页
Chinese Journal of Epidemiology
基金
国家自然科学基金(82192900,82192901,82192904,81390540,91846303)
国家重点研发计划“精准医学研究”重点专项(2016YFC0900500)
中国香港Kadoorie Charitable基金
英国Wellcome Trust(202922/Z/16/Z,088158/Z/09/Z,104085/Z/14/Z)。
