摘要
目的:探究加贝酯联合灯盏花素注射液治疗急性胰腺炎的临床效果。方法:选取2021年1月—2023年1月湖北科技学院附属第二医院收治的急性胰腺炎患者80例,以随机数字表法分为两组,对照组(加贝酯)及观察组(加贝酯联合灯盏花素注射液),各40例。对比两组临床症状改善时间(腹痛消失时间、腹胀消失时间、排便正常时间、排气正常时间)、肠黏膜功能[D-乳酸、内毒素、尿乳果糖(L)/甘露醇(M)]、炎症因子[肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]、肝功能[天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)]、肾功能[肌酐(Cr)、尿素]、心肌酶[乳酸脱氢酶(LDH)、肌酸激酶(CK)]、Toll样受体4(TLR4)mRNA、核因子κB(NF-κB)mRNA表达量。结果:观察组腹痛消失时间、腹胀消失时间、排便正常时间、排气正常时间均短于对照组,差异均有统计学意义(P<0.05)。治疗前,两组D-乳酸、内毒素、尿L/M水平对比,差异均无统计学意义(P>0.05);治疗后,两组D-乳酸、内毒素、尿L/M水平均下降,观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组TNF-α、IL-6、CRP水平对比,差异均无统计学意义(P>0.05);治疗后,两组TNF-α、IL-6、CRP水平均降低,观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组AST、ALT、Cr、尿素对比,差异均无统计学意义(P>0.05);治疗后,两组AST、ALT、Cr、尿素均下降,观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组心肌酶指标、TLR4 mRNA、NF-κB mRNA水平对比,差异均无统计学意义(P>0.05);治疗后,两组LDH、CK、TLR4 mRNA、NF-κB mRNA水平均下降,观察组均低于对照组,差异均有统计学意义(P<0.05)。结论:急性胰腺炎患者采用加贝酯联合灯盏花素注射液治疗效果显著,可降低炎症因子,改善肠黏膜功能,抑制TLR4 mRNA、NF-κB mRNA通路及有关因子表达,保护肝、肾、心功能。
Objective:To investigate the clinical effect of Gabexate combined with Breviscapine Injection in the treatment of acute pancreatitis.Method:A total of 80 patients with acute pancreatitis admitted to the Second Affiliated Hospital of Hubei University of Science and Technology from January 2021 to January 2023 were selected and divided into two groups by random number table method,the control group(Gabexate)and the observation group(Gabexate combined with Breviscapine Injection),with 40 cases in each group.The time of improvement in terms of clinical symptoms(time of disappearance of abdominal pain,disappearance of abdominal distention,normal time of defecation,normal time of exhaustion),intestinal mucosal function[D-lactic acid,endotoxin,urinary lactulose(L)/mannitol(M)],inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C reactive protein(CRP)],liver function[aspartate aminotransferase(AST),alanine aminotransferase(ALT)],renal function[creatinine(Cr),urea],cardiac enzymes[lactate dehydrogenase(LDH),creatine kinase(CK)],Toll like receptor 4(TLR4)mRNA and nuclear factorsκB(NF-κB)mRNA expression levels of the two groups were compared.Result:Abdominal pain disappeared,abdominal distension disappeared,normal defecation and normal exhaust time in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistical significance in the comparison of D-lactic acid,endotoxin and urinary L/M levels between the two groups(P>0.05);after treatment,the levels of D-lactic acid,endotoxin and urinary L/M were decreased in the two groups,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistical significance in the comparison of TNF-α,IL-6 and CRP levels between the two groups(P>0.05);after treatment,the levels of TNF-α,IL-6 and CRP were decreased in the two groups,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistical significance in the comparison of AST,ALT,Cr and urea between the two groups(P>0.05);after treatment,AST,ALT,Cr and urea were decreased in the two groups,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistical significance in the comparison of cardiac enzyme indexes,TLR4 mRNA and NF-κB mRNA levels between the two groups(P>0.05);after treatment,the levels of LDH,CK,TLR4 mRNA and NF-κB mRNA were decreased in the two groups,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:The treatment effect of patients with acute pancreatitis with Gabexate combined with Breviscapine Injection is remarkable,which can reduce inflammatory factors,improve intestinal mucosal function,inhibit the expression of TLR4 mRNA,NF-κB mRNA pathway and related factors,and protect the liver,kidney and heart functions.
作者
高新生
GAO Xinsheng(Department of Gastroenterology,the Second Affiliated Hospital of Hubei University of Science and Technology,Xianning 437000,China)
出处
《中国医学创新》
CAS
2024年第6期5-10,共6页
Medical Innovation of China
关键词
加贝酯
灯盏花素注射液
急性胰腺炎
炎症因子
肝、肾功能
心肌酶
Gabexate
Breviscapine Injection
Acute pancreatitis
Inflammatory factors
Liver and kidney function
Cardiac enzymes
