摘要
精神分裂症发病前存在临床高风险期(CHR),早发现早干预对于疾病的转归和预后至关重要。事件相关电位(ERP)作为一种特殊的脑诱发电位,不同的ERP成分可反映不同认知过程中大脑的神经电生理变化,探寻CHR异常的ERP成分,对疾病的早期识别和转化风险可能有重要的提示作用。本综述发现,P300和MMN对精神病的转化风险有预测作用,其他ERP成分如P50、P1、N400需要更多研究来验证其作为高危人群精神病转化风险标志物的可靠性。
There is a clinical high-risk period(CHR)before the onset of schizophrenia.Early detection and early treatment are crucial for the prognosis of the disease.Event-related potential(ERP)is a special brain evoked potential.Different ERP components can reflect the neuroelectrophysiological changes of the brain in different cognitive processes.Exploring the ERP components of CHR abnormalities may have an important role in the early recognition of diseases and transformation risk.This review found that P300 and MMN have predictive effects on the risk of mental illness conversion,while other ERP components such as P50,P1.and N400 require more research to verify their reliability as risk markers for mental illness conversion in high-risk populations.
作者
郭年春
王婧
于欣
GUO Nianchun;WANG Jing;YU Xin(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Health Disorders(Peking University Sixth Hospital),Beijing 100083,China;The8th Hospital of Shijiazhuang,Shijiazhuang 050081,China)
出处
《中国心理卫生杂志》
CSCD
北大核心
2024年第3期200-205,共6页
Chinese Mental Health Journal
基金
国家自然科学基金——首发难治性精神分裂症的精准识别和治疗新思路(82171500)
石家庄市科学技术研究与发展指导计划——慢性精神分裂症心理社会康复及治疗的研究(171462273)。
关键词
精神分裂症
临床高风险
事件相关电位
综述
schizophrenia
clinical high-risk
event-related potentials
review
