摘要
目的通过数据挖掘研究中医药治疗帕金森病的用药规律。方法收集近5年治疗帕金森病的方剂,建立治疗帕金森病中药库,并通过相关平台与软件分析药物频次、性味归经、药物关联规则等。结果共纳入方剂74首,中药170味。高频药物功效以滋阴养血为主。总药物的四气分析结果以温为主,其次为寒、平;五味结果以甘、苦、辛为主;归经呈肝脾肾心肺排列。关联规则分析得到白芍-钩藤、白芍-何首乌等药对。结论帕金森病以治疗肝肾阴虚为主,重用滋补肝肾之药,并配伍补气养血药等共治震颤症状。
Objective To research the medication regularity of traditional Chinese medicine for Parkinson’s disease through data mining.Methods The prescriptions for treating Parkinson’s disease in the past five years were collected,a database of traditional Chinese medicine for treating Parkinson’s disease was established,and the drug frequency,property and flavor,channel entry,and the drug association rules was analyzed through relevant platforms and software.Results A total of 74 prescriptions and 170 Chinese medicines were included.Highfrequency drugs were chiefly used to nourish yin and blood.The results of the four properties analysis of the total drugs were chiefly warm,followed by cold and calm,and the five flavors are chiefly sweet,bitter and spicy.The meridians were arranged in liver,spleen,kidney,heart and lung.The association rule analysis obtained the white peony-uncaria,white peony-polygonum multiflorum and other drug pairs.Conclusion Parkinson’s disease is chiefly treated with yin deficiency of the liver and kidney,and the drugs for nourishing the liver and kidney are heavily used,and the drugs for tonifying qi and nourishing blood are combined to treat the tremor symptoms.
作者
张汝希
况瑞旭
易亚乔(指导)
黎诗艳
林乐心
陈延杰
孙媛
周千
成绍武
ZHANG Ruxi;KUANG Ruixu;YI Yaqiao;LI Shiyan;LIN Lexin;CHEN Yanjie;SUN Yuan;ZHOU Qian;CHENG Shaowu(Medical School,Hunan University of Chinese Medicine,Hunan Province,Changsha 410208,China;School of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Hunan Province,Changsha 410208,China;School of Integrative Medicine,Hunan University of Chinese Medicine,Hunan Province,Changsha 410208,China)
出处
《光明中医》
2024年第6期1046-1049,共4页
GUANGMING JOURNAL OF CHINESE MEDICINE
基金
国家自然科学基金项目(No.82074046)
湖南省大学生创新创业训练计划项目(No.S202210541124)
湖南省教育厅科研基金重点项目(No.22A0262)
湖南省卫生健康委科研项目(No.202203105682)
湖南省中医药科研计划项目(No.D2022104)
湖南中医药大学校级科研项目(No.2022XJZKA002)。
关键词
颤证
帕金森病
数据挖掘
组方特点
tremor syndrome
Parkinson’s disease
data mining
prescription characteristics
