摘要
目的探讨血清可溶性信号肽-CUB-表皮生长因子样结构域蛋白1(SCUBE1)、脂蛋白磷脂酶A2(Lp-PLA2)与急性ST段抬高型心肌梗死(STEMI)患者冠状动脉高血栓负荷(HTB)的关系。方法选取126例急性STEMI患者(急性STEMI组),根据血栓分级分为HTB患者57例和非HTB患者69例;另选取87名健康体检者为对照组。用酶联免疫吸附法检测血清SCUBE1、Lp-PLA2;用多因素Logistic回归分析急性STEMI患者冠状动脉HTB的影响因素;用受试者工作特征(ROC)曲线评估血清SCUBE1、Lp-PLA2水平对急性STEMI患者冠状动脉HTB的预测价值。结果急性STEMI组血清SCUBE1、Lp-PLA2水平高于对照组(P均<0.05)。HTB患者年龄、吸烟比例、低密度脂蛋白胆固醇、白细胞计数、SCUBE1、Lp-PLA2水平高于非HTB患者(P均<0.05),两者性别、基础疾病、罪犯血管、Gensini评分、左室射血分数比较差异无统计学意义(P均>0.05)。多因素Logistic回归分析显示,年龄增加、吸烟和血清SCUBE1、Lp-PLA2水平升高为急性STEMI患者冠状动脉HTB的独立危险因素(P均<0.05)。ROC曲线分析显示,血清SCUBE1、Lp-PLA2水平联合预测急性STEMI患者冠状动脉HTB的曲线下面积为0.874,大于二者单独预测的0.794、0.791(P均<0.05)。结论急性STEMI患者血清SCUBE1、Lp-PLA2水平升高与冠状动脉HTB密切相关,二者联合检测对急性STEMI患者冠状动脉HTB的预测价值较高。
Objective To investigate the relationships between serum soluble signal peptide-CUB-epithelial growth factor domain-containing protein 1(SCUBE1),lipoprotein phospholipase A2(Lp-PLA2)and coronary artery high thrombus burden(HTB)in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods Totally 126 acute STEMI patients(acute STEMI group)were divided into the HTB group(57 cases)and non-HTB group(69 cases)according to thrombus grading,and 87 healthy people with physical examination in the same period were selected as the control group.Serum SCUBE1 and Lp-PLA2 levels were measured by enzyme-linked immunosorbent assay.Multifactorial logistic regression was used to analyze the influencing factors for coronary HTB in patients with acute STEMI,and receiver operating characteristic(ROC)curve was used to evaluate the the predictive value of serum SCUBE1 and Lp-PLA2 levels on coronary HTB in patients with acute STEMI.Results Serum SCUBE1 and Lp-PLA2 levels were higher in the acute STEMI group than the control group(both P<0.05).The age,smoking proportion,low-density lipoprotein cholesterol,white blood cell count,SCUBE1,and Lp-PLA2 levels of patients with HTB were higher than those of patients without HTB(all P<0.05),and there were no significant differences in gender,underlying diseases,culprit vessels,Gensini scores,or left ventricular ejection fractions between the two groups(all P>0.05).Multifactorial Logistic regression analysis showed that increased age,smoking,and elevated SCUBE1 and Lp-PLA2 were independent risk factors for coronary HTB in patients with acute STEMI(all P<0.05).ROC curve analysis showed that the area under the curve of serum SCUBE1 and Lp-PLA2 levels in predicting the coronary HTB in patients with acute STEMI was 0.874,which was greater than that of serum SCUBE1 and Lp-PLA2 levels individually(0.794 and 0.791)(both P<0.05).Conclusion Elevated serum SCUBE1 and Lp-PLA2 levels in patients with acute STEMI are closely associated with coronary HTB,and the combined detection of serum SCUBE1 and Lp-PLA2 levels has high predictive value for coronary HTB in patients with acute STEMI.
作者
赵景宏
乔彦
张荣驿
邓建平
胡济麟
ZHAO Jinghong;QIAO Yan;ZHANG Rongyi;DENG Jianping;HU Jilin(The Second Clinical Medical College,North Sichuan Medical College,Nanchong 637000,China;不详)
出处
《山东医药》
CAS
2024年第7期33-37,共5页
Shandong Medical Journal
基金
四川省基层卫生事业发展研究项目(SWFZ21-C-68)。
