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从“阴阳平衡”理论探讨慢性胃炎“炎癌转化”机制

"Inflammation Cancer Transformation"of Chronic Gastritis from Perspective of"Yin and Yang Balance"
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摘要 慢性胃炎“炎癌转化”是慢性胃炎从发展、恶变到形成胃癌的过程。在此过程中,多组对立平衡关系被打破,包括原癌基因与抑癌基因、促炎因子与抗炎因子、免疫系统的促进与抑制等,与中医学“阴阳失衡”密切相关。针对慢性胃炎“炎癌转化”的治疗,应以“阴阳”为纲,“阴阳三辨”为法。首辨阴阳属性:或以阴阳运行障碍为主,或以阴阳偏盛偏衰为要,抓准主要矛盾,厘清治疗的主要方向;再辨阴阳失和范围:局限于中焦或波及周身,明晰病情轻重;最后辨阴阳盛衰及其内涵:实热、阴虚、血虚属阳,痰湿、血瘀、阳虚、气虚属阴。以阴阳运行障碍为主者,调节阴阳交感运行;以阴阳盛衰为主者,明晰阴阳内涵,损其有余,补齐不足。 "Inflammation cancer transformation"development is the process from chronic gastritis into gastric cancer.During this process,multiple sets of opposing balance relationships are disrupted,including oncogenes and tumor suppressor genes,pro-inflammatory and anti-inflammatory factors,and the promotion and inhibition of the immune system,which are closely related to the imbalance of Yin and Yang in traditional Chinese medicine.The treatment of chronic gastritis with the transformation of inflammation and cancer should be based on the principle of"Yin and Yang"and the method of"differentiation of Yin and Yang".Distinguish the attributes of Yin and Yang first:either focusing on the obstruction of Yin and Yang movement,or focusing on the imbalance between Yin and Yang,grasping the main contradiction,and clarifying the main direction of treatment;Then,consider the scope of Yin and Yang disharmony:limited to the Zhong Jiao or affecting the entire body,clarifying the severity of the condition;Finally,distinguish the rise and fall of Yin and Yang and their connotations:excess Heat,Yin deficiency and blood deficiency belong to Yang,while Phlegm and Dampness,blood stasis,Yang deficiency and Qi deficiency belong to Yin.For those who suffer from obstacles in the movement of Yin and Yang,regulate the sympathetic movement of Yin and Yang;For those who focus on the rise and fall of Yin and Yang,clarify the connotation of Yin and Yang and treat by damage the surplus and making up for the deficiency.
作者 许可依 胡凯文 孙健豪 吴煜 XU Keyi;HU Kaiwen;SUN Jianhao;WU Yu(Graduate School of Beijing University of Chinese Medicine,Beijing China 100029;Department of Oncology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing China 100091;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing China 100078;Chengdu University of Traditional Chinese Medicine,Chengdu Sichuan China 610075)
出处 《中医学报》 CAS 2024年第2期249-252,共4页 Acta Chinese Medicine
基金 中国中医科学院科技创新工程重大攻关项目(CI2021A01803)。
关键词 慢性胃炎 “炎癌转化” 阴阳平衡 胃癌 调和阴阳 chronic gastritis "inflammatory cancer transformation" Yin and Yang balance gastric cancer reconciling Yin and Yang
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