摘要
目的:探讨纳布啡与右美托咪定联合用药对鲜红斑痣患儿日间光动力治疗后苏醒期疼痛与苏醒质量的影响。方法:按照不同的麻醉镇痛策略将122例行光动力治疗的鲜红斑痣患儿分为对照组与联合组,每组各61例,对照组给予常规麻醉;联合组在对照组基础上采用纳布啡与右美托咪定联合用药,对比两组患儿术中不同时间点生命体征、术中用药量、术后苏醒期躁动及疼痛等情况。结果:两组患儿进入手术室生命体征、术中非干预药物使用量比较,差异均无统计学意义(P>0.05);联合组患儿入麻醉后恢复室(PACU)心率及收缩压低于对照组(P<0.05),舒张压、血氧饱和度(SpO_(2))及呼吸与对照组比较,差异无统计学意义(P>0.05);联合组患儿在PACU内VAS评分及苏醒期躁动发生率评分均低于对照组(P<0.05);联合组患儿出PACU心率及收缩压低于对照组(P<0.05),舒张压、SpO_(2)及呼吸与对照组比较,差异均无统计学意义(P>0.05);联合组患儿复苏时间及并发症发生率与对照组比较,差异均无统计学意义(P>0.05)。结论:纳布啡与右美托咪定联合用药可安全用于鲜红斑痣患儿日间光动力术,有效改善疼痛,降低苏醒期躁动发生率。
Objective:To analyze the effect of the combination of nabuprofen and dexmedetomidine on the pain and quality of awakening in children with bright red nevus after photodynamic surgery.Methods:A total of 122 children with bright red mole who were treated by photodynamic therapy in day surgery center were divided into control group(n=61)and combination group(n=61)according to different anesthesia and analgesia strategies.The control group received routine anesthesia,while the combination group received a combination of nabuprofen and dexmedetomidine on the basis of the control group.The vital signs,intraoperative medication dosage,restlessness during postoperative recovery and pain of the two groups of children at different time points were compared.Results:There was no significant difference between the two groups in the vital signs and the use of non-intervention drugs in the operation room(P>0.05).The heart rate and systolic blood pressure in the recovery room after anesthesia(PACU)of children in the combined group were lower than those in the control group(P<0.05),and the diastolic blood pressure,oxygen saturation(SpO_(2))and respiration were not significantly different from those in the control group(P>0.05).The restlessness and VAS scores of the combined group were lower than those of the control group after awakening(P<0.05).The PACU heart rate and systolic blood pressure after PACU in the combined group were lower than those in the control group(P<0.05),and there was no statistically significant difference in diastolic blood pressure,SpO_(2),and respiration compared to the control group(P>0.05).There was no statistically significant difference in the recovery time and incidence of complications between the combined group and the control group(P>0.05).Conclusion:The combination of nalbuphine and dexmedetomidine can be safely used for daytime photodynamic surgery in children with bright red mole,which can effectively improve pain and reduce the incidence of agitation during recovery.
作者
唐雪姣
梁鹏
TANG Xue-jiao;LIANG Peng(Department of Anesthesiology,West China Hospatal,Sichuan University,West China School of Nursing,Sichuan University,Chengdu 610041,Sichuan,China)
出处
《川北医学院学报》
2024年第1期137-140,共4页
Journal of North Sichuan Medical College
关键词
鲜红斑痣
光动力术
纳布啡
右美托咪定
苏醒期躁动
术后疼痛
Fresh red spot nevus
Photodynamic surgery
Nabuffin
Dexmetomidine
Awakening restlessness
Postoperative pain
