摘要
原发性甲状旁腺功能亢进(PHPT)是一种常见的内分泌疾病,常伴有钙、磷代谢紊乱及多系统病变。手术切除是治疗PHPT的主要手段,随着微创手术的推广应用,术前分子影像学精准定位成为迫切需要。核素显像双时相99mTc-MIBI SPECT/CT、11C-choline及18F-Fluorocholine PET/CT一直是PHPT术前定位研究的热点,现就99mTc-MIBI、11C-choline及18F-Fluorocholine基本显像原理,三种核素显像方式在异位/复发病变、多腺体病变、PTH升高与核素显像结果不一致及既往颈部手术史的PHPT术前定位临床应用优缺点新进展相关文献进行综述。
Primary hyperparathyroidism(PHPT)is a common endocrine disease,often accompanied by calcium and phosphorus metabolism disorders and multi-system lesions.Surgical resection is the main method for the treatment of PHPT.With the popularization and application of minimally invasive surgery,preoperative molecular imaging has become an urgent need for accurate localization.Radionuclide imaging of dual-phase 99mTc-MIBI SPECT/CT,11C-choline and 18F-Fluorocholine PET/CT have always been the focus of preoperative localization research for PHPT.The basic imaging principles of 99mTc-MIBI,11C-choline and 18F-Fluorocholine are presented.The advantages and disadvantages of these radionuclide imaging methods in the clinical applications of PHPT preoperative localization in ectopic/recurrent lesions,polyglandular lesions,inconsistent between PTH elevation with radionuclide imaging findings,and previous neck surgery history were reviewed.
作者
邬心爱
邬永军
王雪梅
WU Xin'ai;WU Yongjun;WANG Xuemei(Department of Nuclear Medicine,Affiliated Hospital of Inner Mongolia Medical University,Key Laboratory of Molecular Imaging of Inner Mongolia Autonomous Region,Hohhot 010000,China;Department of Emergency,Ordos Dongsheng District People's Hospital,Ordos 017000,China)
出处
《分子影像学杂志》
2024年第1期88-92,共5页
Journal of Molecular Imaging
基金
内蒙古自治区卫生健康科技计划项目(202201314)。
