摘要
目的探讨妊娠期肝内胆汁淤积症(ICP)与子痫前期(PE)的相关性。方法选择2013年2月-2021年2月在我院产科分娩的PE 864例(PE组)和同期分娩的非PE 33909例(非PE组)作为研究对象,分析两组中ICP的比例,并进行多因素分析和分层分析探讨ICP与PE的相关性。结果(1)PE组中年龄、BMI及辅助生育受孕、ICP、妊娠期糖尿病、双胎妊娠、抗磷脂综合征和系统性红斑狼疮的比例均显著大于非PE组(P<0.05);(2)多因素分析提示年龄、BMI、辅助生育受孕、ICP、双胎妊娠、系统性红斑狼疮和抗磷脂综合征与PE显著相关(P<0.05),其中ICP对PE的OR值为2.159(95%CI:1.434-3.251,P<0.01);(3)分层分析提示在孕妇年龄<35岁、体重不足(BMI<18.5kg/m^(2))、正常BMI(18.5kg/m^(2)≤BMI<24.0kg/m^(2))、单胎妊娠和初产妇中,ICP与PE显著相关(P<0.05),其OR值分别为2.871(95%CI:1.869-4.410)、3.935(95%CI:1.633-9.483)、1.954(95%CI:1.127-3.386)、2.307(95%CI:1.473-3.613)、2.424(95%CI:1.495-3.930)。结论ICP与PE显著相关,在孕妇年龄小于35岁、BMI<24.0kg/m^(2)、单胎妊娠和初产妇中尤为明显,ICP可能是PE的重要风险因素。
Objective To investigate the correlation between intrahepatic cholestasis of pregnancy(ICP)and preeclampsia(PE).Methods 864 cases of PE(PE group)and 33909 cases of non-PE(non-PE group)who delivered in Peking University Shenzhen Hospital from February 2013 to February 2021 were selected as the study objects.The proportion of ICP in the two groups was analyzed,and the correlation between ICP and PE was analyzed by multivariate analysis and stratified analysis.Results(1)The proportions of age,BMI,mode of conception,ICP,gestational diabetes mellitus,twin pregnancy,antiphospholipid syndrome and systemic lupus erythematosus in PE group were significantly higher than those in non-PE group(P<0.05);(2)Multivariate analysis showed that age,BMI,assisted fertility,ICP,twin pregnancy,systemic lupus erythematosus and antiphospholipid syndrome were significantly correlated with PE(P<0.05),and the OR value of ICP for PE was 2.159(95%CI:1.434-3.251,P<0.01).(3)Stratified analysis indicated that ICP was significantly correlated with PE in pregnant women<35 years old,underweight(BMI<18.5kg/m2),normal BMI(18.5kg/m^(2)≤BMI<24.0kg/m^(2)),single pregnancy and primipara(P<0.05).The OR values were 2.871(95%CI:1.869-4.410)、3.935(95%CI:1.633-9.483)、1.954(95%CI:1.127-3.386)、2.307(95%CI:1.473-3.613)、2.424(95%CI:1.495-3.930)respectively.Conclusion ICP is significantly associated with PE,especially in pregnant women younger than 35 years old,BMI<24.0kg/m^(2),single pregnancy and first-time mothers.ICP may be an important risk factor for PE.
作者
程威
杨璈
钟世林
邓玉清
CHENG Wei;YANG Ao;ZHONG Shi-lin;DENG Yu-qing(Shantou University Medical College,Shantou 515041,Guangdong Province,China;Department of Obstetrics and Gynecology,Peking University Shenzhen Hospital,Shenzhen 518036,Guangdong Province,China;Institute of Obstetrics and Gynecology,Shenzhen PKU-HKUST Medical Center,Shenzhen 518036,Guangdong Province,China;Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases,Shenzhen 518036,Guangdong Province,China)
出处
《罕少疾病杂志》
2024年第1期104-106,共3页
Journal of Rare and Uncommon Diseases
基金
深圳市科技计划项目资助(JCYJ20210324110206017)
深圳市高水平医院建设专项经费资助(粤办函[2019]260号)
深圳市“医疗卫生三名工程”项目资助(SZSM202011016)。
关键词
妊娠期肝内胆汁淤积
子痫前期
初产妇
双胎妊娠
高龄妊娠
相关性
Intrahepatic Cholestasis of Pregnancy
Preeclampsia
Primipara
Twin Pregnancy
Advanced Pregnancy
Correlation
