摘要
目的:探讨阿立哌唑联合丙戊酸钠治疗对躁狂症患者社会功能及血清学指标的影响。方法:选取2021年2月—2023年2月北京市西城区平安医院收治的躁狂症患者80例为观察对象,根据随机数字表法分为观察组和对照组,各40例。观察组给予阿立哌唑联合丙戊酸钠治疗,对照组给予丙戊酸钠治疗。比较两组患者治疗前后Bech-Rafaelsen躁狂量表(BRMS)及社会功能缺陷筛选量表(SDSS)评分,脑源性神经营养因子(BDNF)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)指标,临床疗效和不良反应发生情况。结果:治疗后,两组BRMS和SDSS评分均降低,观察组低于对照组,差异有统计学意义(P<0.001);治疗后,两组血清BDNF和TSH水平升高,T3和T4水平降低,观察组血清BDNF和TSH水平高于对照组,T3和T4水平低于对照组,差异有统计学意义(P<0.05);观察组临床疗效总有效率高于对照组,差异有统计学意义(P<0.001);两组患者治疗期间均未出现明显不良反应。结论:阿立哌唑联合丙戊酸钠治疗躁狂症的临床效果显著,有助于改善患者的躁狂症状、社会功能及血清学指标,且不会增加不良反应。
Objective:To investigate the effects of aripiprazole combined with sodium valproate on social function and serological indexes in patients with mania.Methods:A total of eighty patients with mania treated in Beijing Xicheng District Ping'an Hospital from February 2021 to February 2023 were selected as the observation objects,and were divided into observation group and control group according to random number table method,with forty patients in each group.The observation group was treated with aripiprazole combined with sodium valproate,and the control group was treated with sodium valproate.The scores of Bech-Rafaelsen Mania Rating scale(BRMS)and Social Disability Screening Schedule(SDSS),brain-derived neurotrophic factor(BDNF),triiodothyronine(T3),thyroxine(T4),thyrotropin(TSH)before and after treatment,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results:After treatment,BRMS and SDSS scores were decreased in both groups,and the observation group was lower than the control group,the difference was statistically significant(P<0.001);after treatment,the serum BDNF and TSH levels were increased,T3 and T4 levels were decreased,and the serum BDNF and TSH levels in the observation group were higher than those in the control group,the levels of T3 and T4 were lower than those of control group,and the difference was statistically significant(P<0.05);the total effective rate of clinical curative effect of observation group was higher than that of control group,the difference was statistically significant(P<0.001);there were no obvious adverse reactions during treatment in both groups.Conclusion:Aripiprazole combined with sodium valproate has a significant clinical effect in the treatment of mania,which can help to improve the symptoms of mania,social function and serological indicators of patients,and does not increase adverse reactions.
作者
闫昊
胡晓月
Yan Hao;Hu Xiaoyue(Department of First Ward,Beijing Xicheng District Ping'an Hospital,Beijing 100035,China)
出处
《中外医药研究》
2023年第36期48-50,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
