摘要
糖尿病肾病(DN)是糖尿病重要的并发症之一,发病机制复杂,目前尚未完全阐明。上皮间充质转化(EMT)在DN的发生发展中发挥重要作用。糖原合成激酶-3β(GSK-3β)通过多个信号转导通路参与EMT过程,影响DN的发生进展。本文就GSK-3β参与DN中EMT的相关机制研究进展进行综述。
Diabetic nephropathy(DN)is one of the most important complications of diabetes.Its pathogenesis is complex and has not been fully elucidated.Epithelial-mesenchymal transition(EMT)plays an important role in the development of DN.Relevant data show that glycogen synthesis kinase-3β(GSK-3β)participates in the process of EMT through multiple signaling pathways and affects the occurrence and progression of DN.This article reviews the research progress of GSK-3βinvolved in EMT in DN.
作者
孙宣锋
曹慧霞
焦晓静
张丽娜
阎磊
邵凤民
SUN Xuanfeng;CAO Huixia;JIAO Xiaojing;ZHANG Lina;YAN Lei;SHAO Fengmin(Department of Nephrology,People′s Hospital of Zhengzhou University,Henan Key Laboratory of Renal Immunization,Zhengzhou 450003,Henan Province,China)
出处
《新乡医学院学报》
CAS
2024年第1期77-81,共5页
Journal of Xinxiang Medical University
基金
国家自然科学基金面上项目(编号:81770725)
河南省科技重大专项(编号:201300310700)
河南省科技攻关项目(编号:212102310201)。
关键词
糖原合成激酶-3β
糖尿病肾病
上皮间充质转化
信号通路
glycogen synthesis kinase-3β
diabetic nephropathy
epithelial-mesenchymal transition
signaling pathways
